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Details on Person UniProt:Q9NVP2 ASF1B
| Class:Id | ReferenceGeneProduct:219366 |
|---|---|
| _chainChangeLog | chain:1-202 added on Sat February 7 2015 |
| _displayName | UniProt:Q9NVP2 ASF1B |
| _timestamp | 2024-11-03 20:04:25 |
| chain | chain:1-202 |
| checksum | BD62F726610E3A70 |
| comment | FUNCTION Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:20953179, PubMed:21454524, PubMed:26527279). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Required for gonad development (PubMed:12842904).SUBUNIT Interacts with histone H3 (via C-terminus), including histone H3.1, H3.2 and H3.3, and histone H4; the interaction with H3 is direct (PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16537536, PubMed:22195965). Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex (PubMed:11897662, PubMed:14718166, PubMed:16537536, PubMed:16980972). Interacts with HAT1, NASP and TAF1 (PubMed:12842904). Found in a soluble complex with NASP and histones H3 and H4; the interaction with NASP is probably indirect and mediated by H3-H4 (PubMed:22195965). Interacts with CDAN1 (PubMed:22407294). Found in a cytosolic complex with IPO4 and histones H3 and H4 (PubMed:20953179, PubMed:21454524, PubMed:22407294). Interacts with CREBBP (PubMed:24616510).INTERACTION Highly expressed in testis and at lower levels in colon, small intestine and thymus.PTM Phosphorylated by TLK1 and TLK2.SIMILARITY Belongs to the ASF1 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="20"Histone chaperone ASF1B alternativeName: fullName evidence="18"Anti-silencing function protein 1 homolog B shortName evidence="18"hAsf1 shortName evidence="18"hAsf1b alternativeName: fullName evidence="19"CCG1-interacting factor A-II shortName evidence="19"CIA-II shortName evidence="19"hCIA-II |
| geneName | ASF1B |
| identifier | Q9NVP2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chaperone Chromatin regulator Cytoplasm Developmental protein Differentiation Nucleus Phosphoprotein Proteomics identification Reference proteome Spermatogenesis Transcription Transcription regulation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ASF1B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962178] ENSEMBL:ENSG00000105011 ASF1B [Homo sapiens] |
| secondaryIdentifier | ASF1B_HUMAN Q53G51 Q9NVZ0 |
| sequenceLength | 202 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:417168] ASF1B [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NVP2 ASF1B (219366)
