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Details on Person UniProt:Q5QJU3 ACER2
| Class:Id | ReferenceGeneProduct:219323 |
|---|---|
| _chainChangeLog | chain:1-275 added on Sat February 7 2015 |
| _displayName | UniProt:Q5QJU3 ACER2 |
| _timestamp | 2026-02-20 21:46:31 |
| chain | chain:1-275 |
| checksum | 56FD619B53C296B1 |
| comment | FUNCTION Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20089856, PubMed:20207939). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20089856, PubMed:20207939). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856). Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990). Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876).CATALYTIC ACTIVITY N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enineCATALYTIC ACTIVITY N-eicosanoyl-sphing-4-enine + H2O = eicosanoate + sphing-4-enineCATALYTIC ACTIVITY N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoateCATALYTIC ACTIVITY N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoateCATALYTIC ACTIVITY N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoateCATALYTIC ACTIVITY N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enineCATALYTIC ACTIVITY N-tetracosanoyl-sphing-4-enine + H2O = tetracosanoate + sphing-4-enineCATALYTIC ACTIVITY N-(hexanoyl)sphing-4-enine + H2O = hexanoate + sphing-4-enineCATALYTIC ACTIVITY N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoateCATALYTIC ACTIVITY an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acidCATALYTIC ACTIVITY an N-acylsphinganine + H2O = sphinganine + a fatty acidCOFACTOR Specifically activated by lumenal, but not cytosolic Ca(2+). Inhibited by Zn(2+) or Cu(2+). Mg(2+) or Mn(2+) have no effect on ceramidase activity (PubMed:20089856). Inhibited by De-MAPP (PubMed:20207939).BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 7.5-9.0.PATHWAY Lipid metabolism; sphingolipid metabolism.INTERACTION Highly expressed in placenta.INDUCTION Up-regulated upon serum deprivation (PubMed:16940153). Up-regulated by N-(4-hydroxyphenyl)retinamode/4-HPR (PubMed:20628055). Up-regulated upon DNA damage, in a p53/TP53-dependent manner, resulting in increased levels of sphingosine and sphingosine-1-phosphate (at protein level) (PubMed:26943039, PubMed:28294157, PubMed:29229990).SIMILARITY Belongs to the alkaline ceramidase family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="15"Alkaline ceramidase 2 shortName: AlkCDase 2 shortName: Alkaline CDase 2 shortName: haCER2 ecNumber evidence="7 8"3.5.1.- ecNumber evidence="4 6 7"3.5.1.23 alternativeName: Acylsphingosine deacylase 3-like alternativeName: N-acylsphingosine amidohydrolase 3-like |
| geneName | ACER2 ASAH3L PP11646 |
| identifier | Q5QJU3 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calcium Glycoprotein Golgi apparatus Hydrolase Lipid metabolism Membrane Metal-binding Proteomics identification Reference proteome Sphingolipid metabolism Transmembrane Transmembrane helix Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ACER2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996392] ENSEMBL:ENSG00000177076 ACER2 [Homo sapiens] |
| secondaryIdentifier | ACER2_HUMAN A2A3R8 Q569G5 Q5VZR7 Q71RD2 |
| sequenceLength | 275 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:219324] UniProt:Q5QJU3-2 ACER2 [Homo sapiens] [ReferenceIsoform:219325] UniProt:Q5QJU3-3 ACER2 [Homo sapiens] [ReferenceIsoform:407233] UniProt:Q5QJU3-1 ACER2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:428239] ACER2 [Golgi membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q5QJU3 ACER2 (219323)
