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Details on Person UniProt:Q9ULH0 KIDINS220
| Class:Id | ReferenceGeneProduct:219182 |
|---|---|
| _chainChangeLog | chain:1-1771 added on Fri February 6 2015 |
| _displayName | UniProt:Q9ULH0 KIDINS220 |
| _timestamp | 2026-02-20 21:31:19 |
| chain | chain:1-1771 |
| checksum | FD1F99DB88B6996D |
| comment | FUNCTION Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.SUBUNIT Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner. Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation. Isoform 2 interacts (via C-terminal domain) with MAGI2 isoform 1 (via PDZ domain). Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS. An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts (via PDZ-binding motif) with SNTA1 and SNTB2 (via PDZ domains). Interacts with EPHA4 and PRKD1.INTERACTION Localized at late endosome before or after nerve growth factor (NGF) stimulation.ALTERNATIVE PRODUCTS Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.DOMAIN The transmembrane domain mediates interaction with NTRK1.PTM Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF) (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Kinase D-interacting substrate of 220 kDa alternativeName: Ankyrin repeat-rich membrane-spanning protein |
| geneName | KIDINS220 ARMS KIAA1250 |
| identifier | Q9ULH0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ANK repeat Disease variant Endosome Hereditary spastic paraplegia Intellectual disability Membrane Neurodegeneration Neurogenesis Obesity Phosphoprotein Proteomics identification Reference proteome Repeat Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | KIDINS220 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989021] ENSEMBL:ENSG00000134313 KIDINS220 [Homo sapiens] |
| secondaryIdentifier | KDIS_HUMAN A1L4N4 Q4VC08 Q6MZU2 Q9H889 Q9H9E4 Q9NT37 Q9UF42 |
| sequenceLength | 1771 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:219183] UniProt:Q9ULH0-2 KIDINS220 [Homo sapiens] [ReferenceIsoform:219184] UniProt:Q9ULH0-3 KIDINS220 [Homo sapiens] [ReferenceIsoform:219185] UniProt:Q9ULH0-4 KIDINS220 [Homo sapiens] [ReferenceIsoform:219186] UniProt:Q9ULH0-5 KIDINS220 [Homo sapiens] [ReferenceIsoform:415495] UniProt:Q9ULH0-1 KIDINS220 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:169869] p-Y1095-KIDINS220 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:169880] KIDINS220 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:169859] O4'-phospho-L-tyrosine at 1095 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9ULH0 KIDINS220 (219182)
