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Details on Person UniProt:Q5T2S8 ODAD2
| Class:Id | ReferenceGeneProduct:219141 |
|---|---|
| _chainChangeLog | chain:1-1044 added on Fri February 6 2015 |
| _displayName | UniProt:Q5T2S8 ODAD2 |
| _timestamp | 2024-11-03 19:37:55 |
| chain | chain:1-1044 |
| checksum | C0D869AFC3B03E9D |
| comment | FUNCTION Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule (PubMed:27486780). Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (PubMed:23849778).SUBUNIT Component of the outer dynein arm-docking complex along with ODAD1, ODAD3, and ODAD4. Interacts with CFAP61 (By similarity).INTERACTION Expressed in respiratory epithelial cells (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry. Contrary to the wild-type protein, disease-causing variant Trp-927 is unable to rescue the phenotype (randomization of heart looping) of the morpholino knockdown of the orthologous protein in zebrafish (PubMed:23849778). |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Outer dynein arm-docking complex subunit 2 alternativeName: Armadillo repeat-containing protein 4 |
| geneName | ODAD2 ARMC4 |
| identifier | Q5T2S8 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell projection Ciliopathy Cilium Cilium biogenesis/degradation Cytoplasm Cytoskeleton Kartagener syndrome Methylation Primary ciliary dyskinesia Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ODAD2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000465] ENSEMBL:ENSG00000169126 ODAD2 [Homo sapiens] |
| secondaryIdentifier | ODAD2_HUMAN A8K906 B7Z7I1 Q9H0C0 |
| sequenceLength | 1044 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974597] UniProt:Q5T2S8-1 ODAD2 [Homo sapiens] [ReferenceIsoform:8974598] UniProt:Q5T2S8-2 ODAD2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9962997] ODAD2 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9969581] ODAD2 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q5T2S8 ODAD2 (219141)
