Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q3SXY8 ARL13B
| Class:Id | ReferenceGeneProduct:218953 |
|---|---|
| _chainChangeLog | chain:1-428 added on Fri February 6 2015 |
| _displayName | UniProt:Q3SXY8 ARL13B |
| _timestamp | 2024-11-03 19:35:08 |
| chain | chain:1-428 |
| checksum | 002B38A38D1F7BDD |
| comment | FUNCTION Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze fit; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis (PubMed:38219074). May regulate ARF6- and RAB22A-dependent endocytic recycling traffic (PubMed:23223633).SUBUNIT Monomer (By similarity). Interacts with CIMAP3. Interacts with IFT complex B components IFT46 and IFT74 (By similarity) (PubMed:20643351, PubMed:24339792). Interacts with EXOC2; regulates ARL13B localization to the cilium membrane. Interacts with actin; the interaction mediates colocalization of ARL13B and microtubules (PubMed:23223633).INTERACTION Associates with the cilium membrane via palmitoylation. Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone (PubMed:25138100, PubMed:38219074). Colocalizes with microtubules (PubMed:23223633).ALTERNATIVE PRODUCTS Expressed in the developing brain.DOMAIN The C-terminal domain is required for localization to microtubules and the cell membrane.PTM Sumoylation is required for PKD2 entry into cilium.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Used as a ciliary marker because of its specific localization to microtubule doublets of the ciliary axoneme.SIMILARITY Belongs to the small GTPase superfamily. Arf family.CAUTION Was initially thought to form a homodimer (PubMed:18554500). However, 3D structure of C.reinhardtii ortholog showed that it is probably not the case. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: ADP-ribosylation factor-like protein 13B alternativeName: ADP-ribosylation factor-like protein 2-like 1 shortName: ARL2-like protein 1 |
| geneName | ARL13B ARL2L1 |
| identifier | Q3SXY8 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Cell projection Ciliopathy Cilium Coiled coil Cytoplasm Cytoskeleton Disease variant GTP-binding Isopeptide bond Joubert syndrome Lipoprotein Membrane Nucleotide-binding Palmitate Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ARL13B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998740] ENSEMBL:ENSG00000169379 ARL13B [Homo sapiens] |
| secondaryIdentifier | AR13B_HUMAN D3DN29 G3V1S8 Q504W8 Q8TCL5 |
| sequenceLength | 428 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:218954] UniProt:Q3SXY8-2 ARL13B [Homo sapiens] [ReferenceIsoform:406458] UniProt:Q3SXY8-1 ARL13B [Homo sapiens] [ReferenceIsoform:8972285] UniProt:Q3SXY8-3 ARL13B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5618181] ARL13B [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9640110] Misfolded ARL13B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9640116] Misfolded ARL13B [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9641119] Ub-Misfolded ARL13B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9641129] PolyUb-Misfolded ARL13B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9659986] PolyUb-Misfolded ARL13B [late endosome lumen] [Homo sapiens] [EntityWithAccessionedSequence:9660004] PolyUb-Misfolded ARL13B [lysosomal lumen] [Homo sapiens] [EntityWithAccessionedSequence:9716787] ARL13B [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:9659998] ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q3SXY8 ARL13B (218953)
