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Details on Person PMEPA1 sequesters phosphorylated SMAD2/3

Class:Id	Reaction:2187355
_displayName	PMEPA1 sequesters phosphorylated SMAD2/3
_doRelease	TRUE
_timestamp	2012-05-31 09:39:14
authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
compartment	[Compartment:70101] cytosol [Compartment:171062] early endosome membrane
created	[InstanceEdit:2187350] Orlic-Milacic, M, 2012-04-09
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10
input	[EntityWithAccessionedSequence:2187347] PMEPA1 [early endosome membrane] [Homo sapiens] [DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2187348] TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling
modified	[InstanceEdit:2187532] Orlic-Milacic, M, 2012-04-10 [InstanceEdit:2197658] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2250329] Orlic-Milacic, M, 2012-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PMEPA1 sequesters phosphorylated SMAD2/3
output	[Complex:2187343] p-2S-SMAD2/3:PMEPA1 [early endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:170850] Phosphorylated SMAD2/3 dissociates from TGFBR [Homo sapiens] [Reaction:170868] Activated type I receptor phosphorylates SMAD2/3 directly [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294712] R-HSA-2187355.2
summation	[Summation:2187342] PMEPA1 binds phosphorylated SMAD2 and SMAD3, preventing form...
(hasEvent)	[Pathway:2173788] Downregulation of TGF-beta receptor signaling [Homo sapiens]
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No pathways have been reviewed or authored by PMEPA1 sequesters phosphorylated SMAD2/3 (2187355)