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Details on Person SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B

Class:Id	BlackBoxEvent:2187303
_displayName	SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B
_doRelease	TRUE
_timestamp	2022-05-09 21:48:57
authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2187306] Orlic-Milacic, M, 2012-04-09
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
input	[EntityWithAccessionedSequence:2187305] CDKN2B gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1181277] Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
modified	[InstanceEdit:2187535] Orlic-Milacic, M, 2012-04-10 [InstanceEdit:2197659] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2250343] Orlic-Milacic, M, 2012-05-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9736983] Orlic-Milacic, Marija, 2021-07-15 [InstanceEdit:9773749] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9773751] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B
output	[EntityWithAccessionedSequence:182586] CDKN2B [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9736979] p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter [Homo sapiens] [Reaction:2187309] SMAD2/3:SMAD4 heterotrimer binds SP1 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:2187304] Positive gene expression regulation by 'p-2S-SMAD2,3:SMAD4:SP1:CDKN2B gene [nucleoplasm]'
releaseDate	2012-06-12
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294657] R-HSA-2187303.5
summation	[Summation:2187301] SMAD2/3:SMAD4:SP1 complex binds SP1 and SMAD promoter elemen...
(hasEvent)	[Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [Homo sapiens]
(precedingEvent)	[Reaction:182594] Association of INK4 family proteins with CDK4/6 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775583] Update Tracker - [BlackBoxEvent:2187303] SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B - v78:[add_removeRegulator]
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No pathways have been reviewed or authored by SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (2187303)