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Details on Person Platelet glycoprotein IV (CD36) binds ligands

Class:Id	Reaction:2187264
_displayName	Platelet glycoprotein IV (CD36) binds ligands
_doRelease	TRUE
_timestamp	2014-02-06 22:14:39
authored	[InstanceEdit:3222522] Neyen, Claudine, 2013-03-22 [InstanceEdit:3000476] May, B, 2013-01-26
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2187265] May, B, 2012-04-07
edited	[InstanceEdit:2173787] May, B, 2012-04-02
inferredFrom	[Reaction:2187263] Platelet glycoprotein 4 binds ligands [Mus musculus]
input	[EntityWithAccessionedSequence:51645] 4xPalmC-CD36 [plasma membrane] [Homo sapiens] [DefinedSet:2187232] Ligands of CD36 [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2187106] Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 [LiteratureReference:2187121] Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36 [LiteratureReference:2187132] Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species [LiteratureReference:2187140] Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients [LiteratureReference:2187147] Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells [LiteratureReference:2187087] CD36 is a receptor for oxidized low density lipoprotein [LiteratureReference:2187196] The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein [LiteratureReference:3221841] Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36 [LiteratureReference:3221771] CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions [LiteratureReference:3221755] CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart [LiteratureReference:3221614] CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis [LiteratureReference:3221737] CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3) [LiteratureReference:2187095] CD36 is a sensor of diacylglycerides
modified	[InstanceEdit:2203481] May, B, 2012-04-22 [InstanceEdit:2213042] May, B, 2012-04-28 [InstanceEdit:2230931] May, B, 2012-05-05 [InstanceEdit:3108241] May, B, 2013-02-10 [InstanceEdit:3166793] May, B, 2013-02-23 [InstanceEdit:3221842] May, B, 2013-03-17 [InstanceEdit:3222523] May, B, 2013-03-22 [InstanceEdit:3465590] May, B, 2013-05-17 [InstanceEdit:5258170] May, B, 2014-02-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Platelet glycoprotein IV (CD36) binds ligands
output	[Complex:2187250] Platelet glycoprotein IV:Ligand [plasma membrane] [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3222522] Neyen, Claudine, 2013-03-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654238] R-HSA-2187264.2
summation	[Summation:2213030] CD36 (Platelet glycoprotein IV) binds oxidized LDL (Janabi e...
(hasEvent)	[Pathway:3000471] Scavenging by Class B Receptors [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:2247512] Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed [Homo sapiens] [Reaction:8869667] oxLDL:CD36 binds TLR4:TLR6 [Homo sapiens]
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No pathways have been reviewed or authored by Platelet glycoprotein IV (CD36) binds ligands (2187264)