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Details on Person UniProt:Q4VCS5 AMOT
| Class:Id | ReferenceGeneProduct:218502 |
|---|---|
| _chainChangeLog | chain:1-1084 added on Fri February 6 2015 |
| _displayName | UniProt:Q4VCS5 AMOT |
| _timestamp | 2024-11-03 19:44:35 |
| chain | chain:1-1084 |
| checksum | D7E7021E9535A628 |
| comment | FUNCTION Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866).SUBUNIT Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3 (PubMed:16678097). Interacts with MAGI1 (PubMed:16043488).SUBUNIT Interacts with angiostatin (PubMed:16043488). Interacts with YAP1; the interaction facilitates translocation of YAP1 to the cytoplasm and tight junctions (PubMed:21205866). Interacts with WWTR1/TAZ (via WW domain); the interaction facilitates translocation of WWTR1/TAZ to the cytoplasm (PubMed:21205866).INTERACTION Localized on the cell surface. May act as a transmembrane protein.ALTERNATIVE PRODUCTS Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.DOMAIN The coiled coil domain interacts directly with the BAR domain of ARHGAP17.DOMAIN The angiostatin binding domain (871-1005) allows the binding to angiostatin.PTM Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation.MISCELLANEOUS 'Motus' means 'motility' in Latin.SIMILARITY Belongs to the angiomotin family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Angiomotin |
| geneName | AMOT KIAA1071 |
| identifier | Q4VCS5 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell junction Coiled coil Isopeptide bond Phosphoprotein Proteomics identification Reference proteome Tight junction Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | AMOT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002797] ENSEMBL:ENSG00000126016 AMOT [Homo sapiens] |
| secondaryIdentifier | AMOT_HUMAN Q504X5 Q9HD27 Q9UPT1 |
| sequenceLength | 1084 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:218503] UniProt:Q4VCS5-2 AMOT [Homo sapiens] [ReferenceIsoform:406914] UniProt:Q4VCS5-1 AMOT [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:427897] AMOT [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q4VCS5 AMOT (218502)
