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Details on Person UniProt:Q8INB9-2 Akt
| Class:Id | ReferenceIsoform:218329 |
|---|---|
| _chainChangeLog | chain:1-611 added on Fri February 6 2015 |
| _displayName | UniProt:Q8INB9-2 Akt |
| _timestamp | 2025-02-21 19:56:23 |
| chain | chain:1-611 |
| checksum | C139380152580934 |
| comment | FUNCTION Serine/threonine kinase involved in various developmental processes (PubMed:10587646, PubMed:10962553, PubMed:11740943, PubMed:11872800, PubMed:12172554, PubMed:12893776, PubMed:14525946, PubMed:15466161, PubMed:15712201, PubMed:9601646). During early embryogenesis, acts as a survival protein (PubMed:10962553, PubMed:9601646). During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination (PubMed:11740943). Also regulates tracheal cell migration (PubMed:11740943, PubMed:14525946). Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor (PubMed:10587646, PubMed:10962553, PubMed:11752451, PubMed:12893776, PubMed:24603715, PubMed:25329475, PubMed:29025897). Controls follicle cell size during oogenesis (PubMed:15712201). May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex (PubMed:12172554, PubMed:15466161). Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth (PubMed:10962553).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Interacts with trbl.INTERACTION Recruited to plasma membrane upon activation.ALTERNATIVE PRODUCTS Ubiquitously expressed. Present in ovary, where it is concentrated at the basal side of follicle cells.DEVELOPMENTAL STAGE Expressed both maternally and zygotically. Strongly expressed in embryo and pupa. Weakly expressed in larva. Mildly expressed in adult.DOMAIN Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.PTM Phosphorylated and activated by Pk61C/PDK1 (PubMed:11344272). Phosphorylated on Ser-586 by the TORC2 complex (PubMed:10962553, PubMed:15718470, PubMed:22493059).DISRUPTION PHENOTYPE Death at the first instar larval stage (PubMed:9601646). Conditional RNAi-mediated knockdown in the female germline reduces ovary size (PubMed:24786828). RNAi-mediated knockdown in both larval salivary glands and fat body, results in small salivary glands displaying ectopic lipid storage and reduced expression of CdsA (PubMed:24603715).MISCELLANEOUS Major form.SIMILARITY Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="28"RAC serine/threonine-protein kinase shortName evidence="29"DAkt shortName evidence="28"DRAC-PK shortName evidence="30"Dakt1 ecNumber evidence="24"2.7.11.1 alternativeName: fullName evidence="30"Protein kinase B shortName evidence="30"PKB |
| geneName | Akt Akt1 CG4006 |
| identifier | Q8INB9 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative initiation Apoptosis ATP-binding Cell membrane Cytoplasm Developmental protein Growth regulation Kinase Membrane Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Akt |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | AKT1_DROME Q0KI65 Q24293 Q24469 Q24470 Q7JN11 Q8T9A5 Q9VEY7 |
| sequenceLength | 611 |
| species | [Species:56210] Drosophila melanogaster |
| variantIdentifier | Q8INB9-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8INB9-2 Akt (218329)
