Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O75077 ADAM23
| Class:Id | ReferenceGeneProduct:218000 |
|---|---|
| _chainChangeLog | signal peptide:1-59 added on Fri February 6 2015;propeptide:60-286 added on Fri February 6 2015;chain:287-832 added on Fri February 6 2015 |
| _displayName | UniProt:O75077 ADAM23 |
| _timestamp | 2024-11-03 19:59:39 |
| chain | signal peptide:1-59 propeptide:60-286 chain:287-832 |
| checksum | 7841A9670E1C24EF |
| comment | FUNCTION May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.SUBUNIT Can bind to LGI1 and LGI4 (By similarity). Ligand for integrin alpha-V/beta-3.SUBCELLULAR LOCATION Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.DEVELOPMENTAL STAGE Highly expressed in the fetal brain.DOMAIN A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Disintegrin and metalloproteinase domain-containing protein 23 shortName: ADAM 23 alternativeName: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3 shortName: MDC-3 |
| geneName | ADAM23 MDC3 |
| identifier | O75077 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell adhesion Cell membrane Cleavage on pair of basic residues Disulfide bond EGF-like domain Glycoprotein Membrane Proteomics identification Reference proteome Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ADAM23 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001586] ENSEMBL:ENSG00000114948 ADAM23 [Homo sapiens] |
| secondaryIdentifier | ADA23_HUMAN A2RU59 |
| sequenceLength | 832 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:218001] UniProt:O75077-2 ADAM23 [Homo sapiens] [ReferenceIsoform:218002] UniProt:O75077-3 ADAM23 [Homo sapiens] [ReferenceIsoform:401803] UniProt:O75077-1 ADAM23 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5678676] ADAM23 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75077 ADAM23 (218000)
