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Details on Person UniProt:Q8K348 Acvr1c
| Class:Id | ReferenceGeneProduct:217971 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Fri February 6 2015;chain:26-493 added on Fri February 6 2015 |
| _displayName | UniProt:Q8K348 Acvr1c |
| _timestamp | 2025-08-15 22:05:57 |
| chain | signal peptide:1-25 chain:26-493 |
| checksum | CB9BE5E368CA2D2F |
| comment | FUNCTION Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells (PubMed:18480258, PubMed:36403856). Acts as a positive regulator for macrophage activation partially through down-regulation of PPARG expression (PubMed:32641645).CATALYTIC ACTIVITY L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)CATALYTIC ACTIVITY L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)COFACTOR Binds the type 2 receptor protein ACVR2A.SUBCELLULAR LOCATION Expressed in interdigital regions in developing limb buds.INDUCTION Upon oxidized low-density lipoprotein stimulation in macrophages.DISRUPTION PHENOTYPE Acvr1c mutant embryos develop normally, with none of the known NODAL-related phenotypes found in these mice, suggesting that Acvr1c is not an obligatory component of the NODAL signaling pathway, at least during early development (PubMed:15485907). Acvr1c deleted mice however develop age-dependent metabolic syndromes, including progressive hyperinsulinemia, reduced insulin sensitivity, liver steatosis, impaired glucose tolerance and pancreatic island enlargement (PubMed:18480258).SIMILARITY Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Activin receptor type-1C ecNumber: 2.7.11.30 alternativeName: Activin receptor type IC shortName: ACTR-IC alternativeName: Activin receptor-like kinase 7 shortName: ALK-7 |
| geneName | Acvr1c Alk7 |
| identifier | Q8K348 |
| isSequenceChanged | FALSE |
| keyword | Apoptosis ATP-binding Cell membrane Kinase Magnesium Manganese Membrane Metal-binding Nucleotide-binding Receptor Reference proteome Serine/threonine-protein kinase Signal Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Acvr1c |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ACV1C_MOUSE A2AJR4 |
| sequenceLength | 493 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:1225916] Acvr1c [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:2470468] p-Acvr1c [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q8K348 Acvr1c (217971)
