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Details on Person GRB2:SOS1 binds to HBEGF:p-Y-EGFR

Class:Id	Reaction:2179415
_displayName	GRB2:SOS1 binds to HBEGF:p-Y-EGFR
_doRelease	TRUE
_timestamp	2012-05-31 09:50:15
authored	[InstanceEdit:2186599] Jassal, Bijay, Tripathi, S, 2012-04-04
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2179414] Jassal, B, 2012-04-04
edited	[InstanceEdit:2186599] Jassal, Bijay, Tripathi, S, 2012-04-04
input	[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [Complex:2179410] HB-EGF:p-6Y-EGFR dimer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:179887] Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor [LiteratureReference:179801] Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells
modified	[InstanceEdit:2186600] Jassal, Bijay, 2012-04-04 [InstanceEdit:2203913] Jassal, B, 2012-04-23 [InstanceEdit:2206193] Jassal, Bijay, 2012-04-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GRB2:SOS1 binds to HBEGF:p-Y-EGFR
output	[Complex:2179409] GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:2179387] Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor [Homo sapiens] [Reaction:2179402] Active MMP3 can cleave pro-HBEGF to form active HBEGF [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2206192] D'Eustachio, P, 2012-04-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295150] R-HSA-2179415.2
summation	[Summation:2179394] Cytoplasmic target proteins containing the SH2 domain can bi...
(hasEvent)	[Pathway:2179392] EGFR Transactivation by Gastrin [Homo sapiens]
(precedingEvent)	[Reaction:2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) [Homo sapiens] [Reaction:5672965] RAS GEFs promote RAS nucleotide exchange [Homo sapiens]
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No pathways have been reviewed or authored by GRB2:SOS1 binds to HBEGF:p-Y-EGFR (2179415)