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Details on Person The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

Class:IdLiteratureReference:2179288
_displayNameThe deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling
_timestamp2012-04-03 18:39:49
author[Person:2179283] Wicks, SJ
[Person:2179292] Haros, K
[Person:2179290] Maillard, M
[Person:2179289] Song, L
[Person:2179284] Cohen, RE
[Person:2179286] Dijke, PT
[Person:2179285] Chantry, A
created[InstanceEdit:2179294] Orlic-Milacic, M, 2012-04-03
journalOncogene
pages8080-4
pubMedIdentifier16027725
titleThe deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling
volume24
year2005
(literatureReference)[Summation:2179297] Ubiquitin C-terminal hydrolase UCHL5 (UCH37) deubiquitinates...
[Summation:2179298] Ubiquitin C-terminal hydrolase UCHL5 (UCH37) strongly binds ...
[Summation:2179309] Recombinant mouse Uchl5 (Uch37) exogenously expressed in HEK...
[Summation:2179311] Endogenous UCHL5 and SMAD7 were shown to form a complex in h...
[Summation:2190603] TGF-beta receptor signaling is downregulated by proteasome a...
[Pathway:2173788] Downregulation of TGF-beta receptor signaling [Homo sapiens]
[Reaction:2179291] UCHL5, USP15 deubiquitinate TGFBR1 [Homo sapiens]
[Reaction:2179293] UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 [Homo sapiens]
[Reaction:2179307] Uchl5 is recruited to TGF-beta receptor complex through Smad7 [Homo sapiens]
[Reaction:2179313] Uchl5 deubiquitinates TGFBR1 [Homo sapiens]
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