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Details on Person SMURF2 monoubiquitinates SMAD3

Class:Id	Reaction:2179276
_displayName	SMURF2 monoubiquitinates SMAD3
_doRelease	TRUE
_timestamp	2022-05-10 17:09:24
authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
catalystActivity	[CatalystActivity:2179275] ubiquitin-protein transferase activity of p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2179278] Orlic-Milacic, M, 2012-04-03
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
input	[Complex:2179277] p-T-2S-SMAD2,3:SMAD4:SMURF2 [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2176446] Ablation of Smurf2 reveals an inhibition in TGF-? signalling through multiple mono-ubiquitination of Smad3
modified	[InstanceEdit:2187537] Orlic-Milacic, M, 2012-04-10 [InstanceEdit:2190621] Orlic-Milacic, M, 2012-04-11 [InstanceEdit:2197657] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2250358] Orlic-Milacic, M, 2012-05-15 [InstanceEdit:9773749] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9773751] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9773850] Orlic-Milacic, Marija, 2022-05-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SMURF2 monoubiquitinates SMAD3
output	[EntityWithAccessionedSequence:177103] SMAD4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:177103] SMAD4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:177103] SMAD4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:178202] SMURF2 [nucleoplasm] [Homo sapiens] [DefinedSet:9773846] Ub,p-T,S-SMAD2/3 [nucleoplasm] [Homo sapiens] [DefinedSet:9773846] Ub,p-T,S-SMAD2/3 [nucleoplasm] [Homo sapiens] [DefinedSet:9773846] Ub,p-T,S-SMAD2/3 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2179274] SMURF2 binds SMAD3 phosphorylated in the linker region [Homo sapiens] [Reaction:2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294860] R-HSA-2179276.3
summation	[Summation:2179272] SMURF2 monoubiquitinates SMAD3 on lysine residues in the MH2...
(hasEvent)	[Pathway:2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9754408] Futile Cycle: SMURF2 monoubiquitinates SMAD3 [NegativePrecedingEvent:9754413] Futile Cycle: SMURF2 monoubiquitinates SMAD3
(updatedInstance)	[_UpdateTracker:9774657] Update Tracker - [Reaction:2179276] SMURF2 monoubiquitinates SMAD3 - v81:[add_removeOutput]
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No pathways have been reviewed or authored by SMURF2 monoubiquitinates SMAD3 (2179276)