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Details on Person UniProt:Q08AH3 ACSM2A
| Class:Id | ReferenceGeneProduct:217904 |
|---|---|
| _chainChangeLog | transit peptide:1-46 added on Sat February 7 2015;chain:47-577 added on Sat February 7 2015 |
| _displayName | UniProt:Q08AH3 ACSM2A |
| _timestamp | 2025-02-21 18:33:33 |
| chain | transit peptide:1-46 chain:47-577 |
| checksum | 16167FC69562436F |
| comment | FUNCTION Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity).CATALYTIC ACTIVITY a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY benzoate + ATP + CoA = benzoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY hexanoate + ATP + CoA = hexanoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY decanoate + ATP + CoA = decanoyl-CoA + AMP + diphosphateCOFACTOR Monomer.SUBCELLULAR LOCATION Belongs to the ATP-dependent AMP-binding enzyme family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Acyl-coenzyme A synthetase ACSM2A, mitochondrial ecNumber evidence="1"6.2.1.2 alternativeName: Acyl-CoA synthetase medium-chain family member 2A alternativeName: Benzoate--CoA ligase ecNumber evidence="1"6.2.1.25 alternativeName: Butyrate--CoA ligase 2A alternativeName: Butyryl-coenzyme A synthetase 2A alternativeName: Middle-chain acyl-CoA synthetase 2A |
| geneName | ACSM2A ACSM2 MACS2 |
| identifier | Q08AH3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Fatty acid metabolism Ligase Lipid metabolism Magnesium Metal-binding Mitochondrion Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ACSM2A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999891] ENSEMBL:ENSG00000183747 ACSM2A [Homo sapiens] |
| secondaryIdentifier | ACS2A_HUMAN B3KTT9 O75202 |
| sequenceLength | 577 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:3907281] ACSM2A [mitochondrial matrix] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q08AH3 ACSM2A (217904)
