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Details on Person UniProt:Q9BV23 ABHD6

Class:IdReferenceGeneProduct:217665
_chainChangeLogchain:1-337 added on Fri February 6 2015
_displayNameUniProt:Q9BV23 ABHD6
_timestamp2025-02-21 19:14:56
chainchain:1-337
checksumD87CEE8316F94910
commentFUNCTION Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015).CATALYTIC ACTIVITY Hydrolyzes glycerol monoesters of long-chain fatty acids.CATALYTIC ACTIVITY 1-octanoylglycerol + H2O = octanoate + glycerol + H(+)CATALYTIC ACTIVITY 1-decanoylglycerol + H2O = decanoate + glycerol + H(+)CATALYTIC ACTIVITY 1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)CATALYTIC ACTIVITY 1-tetradecanoylglycerol + H2O = tetradecanoate + glycerol + H(+)CATALYTIC ACTIVITY 2-hexadecanoylglycerol + H2O = glycerol + hexadecanoate + H(+)CATALYTIC ACTIVITY 2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)CATALYTIC ACTIVITY 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)CATALYTIC ACTIVITY 1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)CATALYTIC ACTIVITY 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)CATALYTIC ACTIVITY (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O = (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + (9Z)-octadecenoate + H(+)BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 7.2-9 with 2-arachidonoyglycerol as substrate.INTERACTION Belongs to the AB hydrolase superfamily.
created[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
descriptionrecommendedName: fullName evidence="7"Monoacylglycerol lipase ABHD6 ecNumber evidence="4"3.1.1.23 alternativeName: fullName evidence="1"2-arachidonoylglycerol hydrolase alternativeName: fullName evidence="9"Abhydrolase domain-containing protein 6
geneNameABHD6
identifierQ9BV23
isSequenceChangedFALSE
keyword3D-structure
Endosome
Hydrolase
Lipid metabolism
Lysosome
Membrane
Mitochondrion
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9862192] Weiser, Joel, 2024-02-26
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
nameABHD6
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8989349] ENSEMBL:ENSG00000163686 ABHD6 [Homo sapiens]
secondaryIdentifierABHD6_HUMAN
B2R7Y9
Q6ZMF7
sequenceLength337
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:5694483] ABHD6 [plasma membrane] [Homo sapiens]
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