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Details on Person NEDD4L ubiquitinates SMAD2/3

Class:IdReaction:2176502
_displayNameNEDD4L ubiquitinates SMAD2/3
_doReleaseTRUE
_timestamp2022-05-09 21:48:30
authored[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:2176500] Orlic-Milacic, M, 2012-04-02
edited[InstanceEdit:2187413] Jassal, B, 2012-04-10
[InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
input[Complex:2176495] p-T-2S-SMAD2,3:SMAD4:NEDDL4 [nucleoplasm] [Homo sapiens]
[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2176494] Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling
modified[InstanceEdit:2187537] Orlic-Milacic, M, 2012-04-10
[InstanceEdit:2197657] Orlic-Milacic, M, 2012-04-13
[InstanceEdit:2250326] Orlic-Milacic, M, 2012-05-15
[InstanceEdit:9773749] Orlic-Milacic, Marija, 2022-05-09
[InstanceEdit:9773751] Orlic-Milacic, Marija, 2022-05-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNEDD4L ubiquitinates SMAD2/3
output[Complex:2176504] Ub-p-T-2S-SMAD2,3:SMAD4 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:2176420] NEDD4L [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2012-06-12
reviewed[InstanceEdit:2250308] Huang, Tao, 2012-05-14
[InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2295062] R-HSA-2176502.3
summation[Summation:2176501] NEDD4L ubiquitinates nuclear SMAD2 and SMAD3 phosphorylated ...
(hasEvent)[Pathway:2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity [Homo sapiens]
(precedingEvent)[BlackBoxEvent:2176503] Degradation of SMAD2/3:SMAD4 complex [Homo sapiens]
[NegativePrecedingEvent:9754415] Futile Cycle: NEDD4L ubiquitinates SMAD2/3
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No pathways have been reviewed or authored by NEDD4L ubiquitinates SMAD2/3 (2176502)