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Details on Person Ubiquitinated SMAD2 undergoes proteasome-dependent degradati...
| Class:Id | Summation:2176444 |
|---|---|
| _displayName | Ubiquitinated SMAD2 undergoes proteasome-dependent degradati... |
| _timestamp | 2012-04-16 20:59:00 |
| created | [InstanceEdit:2176447] Orlic-Milacic, M, 2012-04-02 |
| literatureReference | [LiteratureReference:175938] Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase [LiteratureReference:2176446] Ablation of Smurf2 reveals an inhibition in TGF-? signalling through multiple mono-ubiquitination of Smad3 |
| modified | [InstanceEdit:2197664] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2199157] Orlic-Milacic, M, 2012-04-16 |
| text | Ubiquitinated SMAD2 undergoes proteasome-dependent degradation. Therefore, SMURF2 decreases the level of SMAD2 in the cell, irrespective of TGF-beta signaling, and may regulate the competence of a cell to respond to TGF-beta signaling (Zhang et al. 2001). These findings are contradicted by a recent study of Smurf2 knockout mice, where Smad2 protein levels were found to be unaltered in the absence of Smurf2 (Tang et al. 2011). |
| (summation) | [BlackBoxEvent:2176452] Degradation of ubiquitinated SMAD2 [Homo sapiens] [BlackBoxEvent:9846251] GOCAM Degradation of ubiquitinated SMAD2 [Homo sapiens] |
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No pathways have been reviewed or authored by Ubiquitinated SMAD2 undergoes proteasome-dependent degradati... (2176444)
