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Details on Person NEDD4L ubiquitin ligase binds SMAD7

Class:Id	Reaction:2176416
_displayName	NEDD4L ubiquitin ligase binds SMAD7
_doRelease	TRUE
_timestamp	2012-05-31 09:51:20
authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2176414] Orlic-Milacic, M, 2012-04-02
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10
inferredFrom	[Reaction:2176430] NEDD4L binds Smad7 [Homo sapiens]
input	[EntityWithAccessionedSequence:178197] SMAD7 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2176420] NEDD4L [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2176422] NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor
modified	[InstanceEdit:2176433] Orlic-Milacic, M, 2012-04-02 [InstanceEdit:2176441] Orlic-Milacic, M, 2012-04-02 [InstanceEdit:2187532] Orlic-Milacic, M, 2012-04-10 [InstanceEdit:2197658] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2250325] Orlic-Milacic, M, 2012-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NEDD4L ubiquitin ligase binds SMAD7
output	[Complex:2176418] SMAD7:NEDD4L [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 [Homo sapiens] [Reaction:9736970] WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter [Homo sapiens] [Reaction:5252001] ATP1B4 binds SNW1 [Homo sapiens]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295193] R-HSA-2176416.2
summation	[Summation:2176434] NEDD4L ubiquitin ligase, structurally similar to SMURF ubiqu...
(hasEvent)	[Pathway:2173788] Downregulation of TGF-beta receptor signaling [Homo sapiens]
(precedingEvent)	[Reaction:2176417] SMAD7:NEDD4L complex translocates to the cytosol [Homo sapiens]
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No pathways have been reviewed or authored by NEDD4L ubiquitin ligase binds SMAD7 (2176416)