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Details on Person UniProt:Q7Z5R6 APBB1IP
| Class:Id | ReferenceGeneProduct:217574 |
|---|---|
| _chainChangeLog | chain:1-666 added on Sat February 7 2015 |
| _displayName | UniProt:Q7Z5R6 APBB1IP |
| _timestamp | 2024-11-03 20:17:40 |
| chain | chain:1-666 |
| checksum | 525C906C490D8D97 |
| comment | FUNCTION Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.SUBUNIT Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, TLN1, VASP, VCL and ENAH.INTERACTION Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity).ALTERNATIVE PRODUCTS Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.INDUCTION By all-trans-retinoic acid (ATRA).DOMAIN The two Pro-rich regions are required for the suppression of AP1 transcription activity.SIMILARITY Belongs to the MRL family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein alternativeName: APBB1-interacting protein 1 alternativeName: Proline-rich EVH1 ligand 1 shortName: PREL-1 alternativeName: Proline-rich protein 73 alternativeName: Rap1-GTP-interacting adapter molecule shortName: RIAM alternativeName: Retinoic acid-responsive proline-rich protein 1 shortName: RARP-1 |
| geneName | APBB1IP PREL1 RARP1 RIAM |
| identifier | Q7Z5R6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell junction Cell membrane Cell projection Cytoplasm Cytoskeleton Membrane Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | APBB1IP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989945] ENSEMBL:ENSG00000077420 APBB1IP [Homo sapiens] |
| secondaryIdentifier | AB1IP_HUMAN Q8IWS8 Q8IYL7 Q8IZZ7 |
| sequenceLength | 666 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965040] UniProt:Q7Z5R6-1 APBB1IP [Homo sapiens] [ReferenceIsoform:8965041] UniProt:Q7Z5R6-2 APBB1IP [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:354081] APBB1IP [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q7Z5R6 APBB1IP (217574)
