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Details on Person UniProt:Q7Z4T9 CFAP91
| Class:Id | ReferenceGeneProduct:217561 |
|---|---|
| _chainChangeLog | chain:1-603 added on Fri February 6 2015 |
| _displayName | UniProt:Q7Z4T9 CFAP91 |
| _timestamp | 2026-02-20 21:47:45 |
| chain | chain:1-767 |
| checksum | 7EBE6F798C496845 |
| comment | FUNCTION Involved in sperm flagellum axonemal organization and function (PubMed:12223483, PubMed:32161152). May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).SUBUNIT Interacts with MYCBP and AKAP1 (PubMed:12223483). Part of a complex containing MYCBP, AKAP1 and PRKAR2B. Interacts with CFAP61 (By similarity). Interacts with CFAP70 (By similarity).SUBUNIT Does not interact with MYCBP.INTERACTION Localized in the neck of the sperm.SUBCELLULAR LOCATION Additional isoforms may exist.TISSUE SPECIFICITY Strongly expressed in the liver.TISSUE SPECIFICITY Widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, the epithelium of cauda and the corpus epididymis, as well as the spermatid and mature sperm. Also expressed in Leydig cells.PTM Phosphorylated by PKA.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be produced by alternative promoter usage.SIMILARITY Belongs to the CFAP91 family.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="16"Cilia- and flagella-associated protein 91 shortName evidence="16"CFAP91 alternativeName: fullName evidence="13"AMY-1-associating protein expressed in testis 1 shortName evidence="13"AAT-1 alternativeName: fullName evidence="11"MYCBP/AMY-1-associated testis-expressed protein 1 alternativeName: fullName evidence="11"Protein MAATS1 |
| geneName | CFAP91 AAT1 C3orf15 MAATS1 |
| identifier | Q7Z4T9 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative promoter usage Alternative splicing Cell projection Cytoplasm Cytoskeleton Differentiation Mitochondrion Phosphoprotein Proteomics identification Reference proteome Spermatogenesis |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CFAP91 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997065] ENSEMBL:ENSG00000183833 CFAP91 [Homo sapiens] |
| secondaryIdentifier | CFA91_HUMAN A0AVK2 A8K1J9 B3KP23 B4DG52 B4DZ14 C9JUG4 Q68DX2 Q8TD41 Q96A45 Q96JE8 |
| sequenceLength | 767 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:217562] UniProt:Q7Z4T9-2 CFAP91 [Homo sapiens] [ReferenceIsoform:217563] UniProt:Q7Z4T9-3 CFAP91 [Homo sapiens] [ReferenceIsoform:217565] UniProt:Q7Z4T9-5 CFAP91 [Homo sapiens] [ReferenceIsoform:409463] UniProt:Q7Z4T9-1 CFAP91 [Homo sapiens] [ReferenceIsoform:8969264] UniProt:Q7Z4T9-6 CFAP91 [Homo sapiens] [ReferenceIsoform:8969265] UniProt:Q7Z4T9-7 CFAP91 [Homo sapiens] [ReferenceIsoform:8969266] UniProt:Q7Z4T9-8 CFAP91 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9966662] CFAP91 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9969384] CFAP91 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q7Z4T9 CFAP91 (217561)
