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Details on Person UniProt:Q30154 HLA-DRB5
| Class:Id | ReferenceGeneProduct:217410 |
|---|---|
| _chainChangeLog | signal peptide:1-29 added on Fri February 6 2015;chain:30-266 added on Fri February 6 2015 |
| _displayName | UniProt:Q30154 HLA-DRB5 |
| _timestamp | 2024-11-03 20:09:44 |
| chain | signal peptide:1-29 chain:30-266 |
| checksum | 0D4335BAEEA6AF22 |
| comment | FUNCTION Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.SUBUNIT Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.INTERACTION The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.PTM Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to down-regulation of MHC class II.POLYMORPHISM The following alleles of DRB5 are known: DRB5*01:01, DRB5*01:02, DRB5*01:03, DRB5*01:04, DRB5*01:05, DRB5*01:06, DRB5*01:07, DRB5*01:09, DRB5*01:11, DRB5*01:12 DRB5*01:13, DRB5*01:14, DRB5*02:02, DRB5*02:03, DRB5*02:04, DRB5*02:05. The sequence shown is that of DRB5*01:01.SIMILARITY Belongs to the MHC class II family.CAUTION HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: HLA class II histocompatibility antigen, DR beta 5 chain alternativeName: DR beta-5 alternativeName: DR2-beta-2 alternativeName: Dw2 alternativeName: MHC class II antigen DRB5 |
| geneName | HLA-DRB5 |
| identifier | Q30154 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Adaptive immunity Cell membrane Direct protein sequencing Disulfide bond Endoplasmic reticulum Endosome Glycoprotein Golgi apparatus Immunity Lysosome Membrane MHC II Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HLA-DRB5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993001] ENSEMBL:ENSG00000198502 HLA-DRB5 [Homo sapiens] |
| secondaryIdentifier | DRB5_HUMAN B2RBV6 C7C4X3 O00157 O00283 O46700 Q29703 Q29787 Q29788 Q30126 Q30150 Q30199 Q6SJR2 Q7M2H9 Q8HWS7 Q8WLR5 Q9MY54 Q9XRX6 |
| sequenceLength | 266 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1235083] HLA class II histocompatibility antigen, DR beta 5 chain [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:2130326] HLA class II histocompatibility antigen, DR beta 5 chain [transport vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:2130357] HLA class II histocompatibility antigen, DR beta 5 chain [trans-Golgi network membrane] [Homo sapiens] [EntityWithAccessionedSequence:2130361] HLA class II histocompatibility antigen, DR beta 5 chain [lumenal side of endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:2130382] HLA class II histocompatibility antigen, DR beta 5 chain [endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:2130548] HLA class II histocompatibility antigen, DR beta 5 chain [clathrin-coated endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:2130591] HLA class II histocompatibility antigen, DR beta 5 chain [lysosomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:2130691] HLA class II histocompatibility antigen, DR beta 5 chain [ER to Golgi transport vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:2214365] HLA class II histocompatibility antigen, DR beta 5 chain [Golgi membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q30154 HLA-DRB5 (217410)
