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Details on Person UniProt:Q3SYX9 ARPC5
| Class:Id | ReferenceGeneProduct:217378 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-151 added on Fri February 6 2015;initiator methionine:1 for 217378 removed on Fri Nov 03 2023;initiator methionine: for 217378 added on Fri Nov 03 2023;initiator methionine: for 217378 removed on Fri Aug 15 2025;initiator methionine:1 for 217378 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q3SYX9 ARPC5 |
| _timestamp | 2025-08-15 21:51:10 |
| chain | initiator methionine:1 chain:2-151 |
| checksum | F39FB10DC68E6F79 |
| comment | FUNCTION Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).SUBUNIT Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.SUBCELLULAR LOCATION Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.SIMILARITY Belongs to the ARPC5 family. |
| created | [InstanceEdit:217379] Matthews, L, 2008-03-26 22:25:16 |
| description | recommendedName: Actin-related protein 2/3 complex subunit 5 alternativeName: Arp2/3 complex 16 kDa subunit shortName: p16-ARC |
| geneName | ARPC5 |
| identifier | Q3SYX9 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Cell projection Cytoplasm Cytoskeleton Nucleus Reference proteome Ubl conjugation |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ARPC5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ARPC5_BOVIN |
| sequenceLength | 151 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:419930] ARPC5 [cytosol] [Bos taurus] |
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No pathways have been reviewed or authored by UniProt:Q3SYX9 ARPC5 (217378)
