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Details on Person In mammals, C6 interacts with C5b through a metastable bindi...
| Class:Id | Summation:2173494 |
|---|---|
| _displayName | In mammals, C6 interacts with C5b through a metastable bindi... |
| _timestamp | 2012-12-19 00:22:34 |
| created | [InstanceEdit:2173495] Shamovsky, V, 2012-03-30 |
| modified | [InstanceEdit:2532785] Shamovsky, V, 2012-10-18 [InstanceEdit:2859048] Shamovsky, V, 2012-12-19 |
| text | In mammals, C6 interacts with C5b through a metastable binding site to form a soluble C5b:C6 dimer. Chicken complement component C6 was cloned and characterized [Mikrou A and Zarkadis IK 2010]. It shows 81% of amino acid identity to the predicted sequence of zebra finch C6, followed by human, frog and trout counterparts with 58%, 56%, and 44% identity, respectively. Chicken C6 contains the same structural motifs as those found in mammalian terminal complement components (TSP1, LDLa, MACPF, EGF). In addition, like mammalian C6/C7 components, chicken C6 contains two complement control protein (CCP) motifs. Chicken C6 carries two copies of the FIMAC domain, which has been implicated in the interaction of mammalian C6/C7 proteins with C5. Chicken C6 mRNA expression was detected in various tissues - liver, brain, heart, kidney [Mikrou A and Zarkadis IK 2010]. |
| (summation) | [Reaction:2132284] Formation of C5b:C6 [Gallus gallus] |
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