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Details on Person FMO1:FAD N-oxidises TAM

Class:IdReaction:217255
_displayNameFMO1:FAD N-oxidises TAM
_doReleaseTRUE
_timestamp2023-08-22 22:22:21
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:217265] N,N-dimethylaniline monooxygenase activity of FMO1:FAD [endoplasmic reticulum membrane]
compartment[Compartment:17960] smooth endoplasmic reticulum
created[InstanceEdit:217275] Jassal, B, 2008-03-26 09:20:04
edited[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
input[SimpleEntity:113534] O2 [endoplasmic reticulum lumen]
[SimpleEntity:113601] NADPH [endoplasmic reticulum lumen]
[SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
[ChemicalDrug:9838650] TAM [endoplasmic reticulum lumen]
literatureReference[LiteratureReference:217273] Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin
modified[InstanceEdit:217278] Jassal, B, 2008-03-26 09:21:20
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351778] Jassal, Bijay, 2008-05-28
[InstanceEdit:352324] Jassal, B, 2008-06-02 12:56:30
[InstanceEdit:389952] Jassal, Bijay, 2009-01-21
[InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9838651] D'Eustachio, Peter, 2023-06-23
[InstanceEdit:9842210] Matthews, Lisa, 2023-08-22
nameFMO1:FAD N-oxidises TAM
FMO1 N-oxidizes the anti-cancer drug tamoxifen
output[SimpleEntity:217269] TAMO [endoplasmic reticulum lumen]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
[SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen]
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2008-06-30
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
[InstanceEdit:9842118] D'Eustachio, Peter, 2023-08-18
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361950] R-HSA-217255.3
structureModified[InstanceEdit:9838651] D'Eustachio, Peter, 2023-06-23
summation[Summation:217260] Tamoxifen (TAM) is an antiestrogen and currently used extens...
(hasEvent)[Pathway:217271] FMO oxidises nucleophiles [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791578] Update Tracker - [Reaction:217255] FMO1:FAD N-oxidises TAM - v28:[addInput]
[_UpdateTracker:9842316] Update Tracker - [Reaction:217255] FMO1:FAD N-oxidises TAM - v86:[add_removeInput]
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No pathways have been reviewed or authored by FMO1:FAD N-oxidises TAM (217255)
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