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Details on Person Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB

Class:Id	Reaction:2172183
_displayName	Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB
_doRelease	TRUE
_timestamp	2017-12-06 21:09:21
authored	[InstanceEdit:2424242] Orlic-Milacic, M, 2012-07-20
catalystActivity	[CatalystActivity:2311326] cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:2172181] Orlic-Milacic, M, 2012-03-28
edited	[InstanceEdit:2426592] Gillespie, ME, 2012-08-07
inferredFrom	[Reaction:2422970] Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB [Homo sapiens]
input	[Complex:2172177] GORASP1:GOLGA2:USO1:RAB1:GTP [Golgi membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:162969] Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling [LiteratureReference:2245207] Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis [LiteratureReference:2311330] The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo [LiteratureReference:2311341] Rab1 interaction with a GM130 effector complex regulates COPII vesicle cis--Golgi tethering [LiteratureReference:213386] The localization of human cyclins B1 and B2 determines CDK1 substrate specificity and neither enzyme requires MEK to disassemble the Golgi apparatus [LiteratureReference:2422384] The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b [LiteratureReference:2463817] Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2 [LiteratureReference:2463829] Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner [LiteratureReference:2463836] The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner [LiteratureReference:213384] Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus
modified	[InstanceEdit:2172191] Orlic-Milacic, M, 2012-03-29 [InstanceEdit:2245209] Orlic-Milacic, M, 2012-05-10 [InstanceEdit:2311327] Orlic-Milacic, M, 2012-06-05 [InstanceEdit:2311333] Orlic-Milacic, M, 2012-06-05 [InstanceEdit:2311344] Orlic-Milacic, M, 2012-06-05 [InstanceEdit:2311347] Orlic-Milacic, M, 2012-06-06 [InstanceEdit:2422394] Orlic-Milacic, M, 2012-07-18 [InstanceEdit:2422981] Orlic-Milacic, M, 2012-07-19 [InstanceEdit:2426699] Orlic-Milacic, M, 2012-08-08 [InstanceEdit:2457760] Orlic-Milacic, M, 2012-08-28 [InstanceEdit:2463825] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:2463831] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:2463839] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:2463849] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:2463853] Orlic-Milacic, M, 2012-08-30 [InstanceEdit:2466353] Matthews, L, 2012-09-07 [InstanceEdit:2466354] Matthews, L, 2012-09-07 [InstanceEdit:2507814] Orlic-Milacic, M, 2012-10-04 [InstanceEdit:9032153] Orlic-Milacic, Marija, 2017-12-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB
output	[Complex:2172185] p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP [Golgi membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:2311342] USO1 homodimer [ER to Golgi transport vesicle membrane] [Homo sapiens]
precedingEvent	[Reaction:170161] Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B [Homo sapiens] [Reaction:162657] Inactivation of Myt1 kinase [Homo sapiens] [Reaction:170120] Translocation of Cdc25B to the cytoplasm [Homo sapiens] [Reaction:170072] Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2463852] Wang, Yanzhuang, 2012-08-19 [InstanceEdit:2463846] Colanzi, Antonino, 2012-08-21 [InstanceEdit:2507813] Malhotra, Vivek, 2012-08-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464977] R-HSA-2172183.3
summation	[Summation:2311346] GORASP1 (GRASP65) and GOLGA2 (GM130) form a complex on cis-G...
(hasEvent)	[Pathway:162658] Golgi Cisternae Pericentriolar Stack Reorganization [Homo sapiens]
(precedingEvent)	[Reaction:2172194] Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) [Homo sapiens] [BlackBoxEvent:2314569] GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi [Homo sapiens]
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