Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person UniProt:P53033 RFC2

Class:IdReferenceGeneProduct:217213
_chainChangeLogchain:1-359 added on Sat February 7 2015
_displayNameUniProt:P53033 RFC2
_timestamp2025-05-21 21:14:35
chainchain:1-359
checksumA2FD38F964CD11F9
commentFUNCTION Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (By similarity). This subunit binds ATP (By similarity).SUBUNIT Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA. Forms an heterotetrameric complex with RFC3, RFC4 and RFC5; this complex has ATPase activity but is not stimulated by PCNA. The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17.SUBCELLULAR LOCATION Belongs to the activator 1 small subunits family.
created[InstanceEdit:217050] Saxena, A, 2008-03-25 20:36:09
descriptionrecommendedName: Replication factor C subunit 2 alternativeName: Activator 1 40 kDa subunit shortName: A1 40 kDa subunit alternativeName: Activator 1 subunit 2 alternativeName: Replication factor C 40 kDa subunit shortName: RF-C 40 kDa subunit shortName: RFC40
geneNameRFC2
identifierP53033
isSequenceChangedFALSE
keywordATP-binding
DNA replication
Nucleotide-binding
Nucleus
Reference proteome
modified[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:9037114] Weiser, JD
[InstanceEdit:9637257] Weiser, JD
[InstanceEdit:9657908] Weiser, JD
[InstanceEdit:9676415] Weiser, JD
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
nameRFC2
referenceDatabase[ReferenceDatabase:2] UniProt
secondaryIdentifierRFC2_CHICK
sequenceLength359
species[Species:49591] Gallus gallus
(referenceEntity)[EntityWithAccessionedSequence:217185] RFC2 [nucleoplasm] [Gallus gallus]
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