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Details on Person Activation and association of ATM kinase at the DNA damage sites

Class:Id	Reaction:217204
_displayName	Activation and association of ATM kinase at the DNA damage sites
_doRelease	TRUE
_timestamp	2011-11-23 11:17:16
authored	[InstanceEdit:209713] Saxena, A, 2008-01-04 18:30:50
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:217050] Saxena, A, 2008-03-25 20:36:09
edited	[InstanceEdit:418967] D'Eustachio, P, 2009-04-27 17:09:41
input	[Complex:351411] Dimeric ATM [nucleoplasm] [Gallus gallus]
literatureReference	[LiteratureReference:216936] ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin [LiteratureReference:217048] Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation [LiteratureReference:351419] Molecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domain
modified	[InstanceEdit:351413] Saxena, A, 2008-05-22 20:44:09 [InstanceEdit:374078] Saxena, A, 2008-07-25 17:02:19 [InstanceEdit:399968] D'Eustachio, P, 2009-03-23 22:14:23 [InstanceEdit:418476] D'Eustachio, P, 2009-04-22 20:40:00 [InstanceEdit:418618] D'Eustachio, P, 2009-04-24 15:53:07 [InstanceEdit:418633] D'Eustachio, P, 2009-04-24 22:33:38 [InstanceEdit:418966] D'Eustachio, P, 2009-04-27 17:13:45 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation and association of ATM kinase at the DNA damage sites
output	[EntityWithAccessionedSequence:217182] Activated-ATM kinase [nucleoplasm] [Gallus gallus] [EntityWithAccessionedSequence:217182] Activated-ATM kinase [nucleoplasm] [Gallus gallus]
precedingEvent	[Reaction:217209] Generation of a DNA double strand break [Gallus gallus]
regulatedBy	[Requirement:265837] Requirement by 'NBS, Nijmegen breakage syndrome protein 1 homolog [nucleoplasm]' [Requirement:351448] Requirement by 'MRE11-RAD50-NBS1 complex [nucleoplasm]'
releaseDate	2009-06-01
reviewed	[InstanceEdit:418616] Borowiec, JA, 2009-04-23 20:19:22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016705] R-GGA-217204.3
summation	[Summation:217024] ATM, a serine-threonine kinase, belongs to a large family wi...
(hasEvent)	[Pathway:217106] Chk1-controlled and DNA-damage induced centrosome duplication [Gallus gallus] [Pathway:351442] ATM mediated response to DNA double-strand break [Gallus gallus]
(precedingEvent)	[Pathway:351433] ATM mediated phosphorylation of repair proteins [Gallus gallus] [Reaction:351434] Phosphorylation of H2AX at S139 by ATM at the site of DSB [Gallus gallus]
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No pathways have been reviewed or authored by Activation and association of ATM kinase at the DNA damage sites (217204)