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Details on Person UniProt:P37383 RAD51A
| Class:Id | ReferenceGeneProduct:217078 |
|---|---|
| _chainChangeLog | chain:1-339 added on Fri February 6 2015 |
| _displayName | UniProt:P37383 RAD51A |
| _timestamp | 2023-11-03 15:11:18 |
| chain | chain:1-339 |
| checksum | 549C59DBD3529DA4 |
| comment | FUNCTION Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.SUBUNIT Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.SUBCELLULAR LOCATION Accumulated at sites of DNA damage. Recruited to stalled replication forks during replication stress.TISSUE SPECIFICITY Expressed at high levels in lymphoid and reproductive organs.SIMILARITY Belongs to the RecA family. RAD51 subfamily. |
| created | [InstanceEdit:217050] Saxena, A, 2008-03-25 20:36:09 |
| description | recommendedName: DNA repair protein RAD51 homolog 1 |
| geneName | RAD51A RAD51 |
| identifier | P37383 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Chromosome Cytoplasm DNA-binding Nucleotide-binding Nucleus Reference proteome |
| modified | [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | RAD51A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RAD51_CHICK |
| sequenceLength | 339 |
| species | [Species:49591] Gallus gallus |
| (referenceEntity) | [EntityWithAccessionedSequence:216957] phospho-RAD51 [nucleoplasm] [Gallus gallus] [EntityWithAccessionedSequence:216997] RAD51 [nucleoplasm] [Gallus gallus] |
| (referenceSequence) | [ModifiedResidue:217125] O4'-phospho-L-tyrosine at 46 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P37383 RAD51A (217078)
