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Details on Person ATM, a serine-threonine kinase, belongs to a large family wi...

Class:IdSummation:217024
_displayNameATM, a serine-threonine kinase, belongs to a large family wi...
_timestamp2009-02-23 15:56:28
created[InstanceEdit:217050] Saxena, A, 2008-03-25 20:36:09
literatureReference[LiteratureReference:83540] DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
modified[InstanceEdit:265791] Saxena, A, 2008-04-21 13:32:14
[InstanceEdit:351413] Saxena, A, 2008-05-22 20:44:09
[InstanceEdit:374078] Saxena, A, 2008-07-25 17:02:19
[InstanceEdit:391641] Saxena, A, 2009-02-23 15:55:32
textATM, a serine-threonine kinase, belongs to a large family with phosphatiylinositol kinase domains at their extreme C termini. DNA double strand breaks induced by IR and other cellular insults induce ATM phosphorylation. Chicken DT 40 cells are p53-null and serve as an excellent tool to reveal p53-independent functions of ATM during cell cycle checkpoint signaling and during DNA repair. In a corresponding human reaction, DNA damage activates ATM through intermolecular autophosphorylation (at Ser 1981) and dimer dissociation. However, in chicken ATM, this site is not conserved and some agents such as okadaic acid induce ATM autophosphorylation but fail to activate ATM kinase activity. The role of autophosphorylation in activation of the chicken ATM kinase is thus not completely understood. In vertebrate cells, ATM is directly activated by agents that modify free -SH groups, and induces a significant downstream response. ATM activation by DNA damage, on the other hand, requires NBS1 and a functional MRN-complex to be recruited to the DNA damage site. DNA damage-dependent activation leads to subsequent phosphorylation of ATM target proteins such as gamma-H2AX, NBS1, CHK1, CHK2, SMC1, etc.
(summation)[Reaction:217204] Activation and association of ATM kinase at the DNA damage sites [Gallus gallus]
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