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Details on Person Phosphorylation of Chk1 by ATR

Class:Id	Reaction:216941
_displayName	Phosphorylation of Chk1 by ATR
_doRelease	TRUE
_timestamp	2011-11-23 11:14:14
authored	[InstanceEdit:209713] Saxena, A, 2008-01-04 18:30:50
catalystActivity	[CatalystActivity:217159] protein serine/threonine kinase activity of ATR [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:217050] Saxena, A, 2008-03-25 20:36:09
edited	[InstanceEdit:418967] D'Eustachio, P, 2009-04-27 17:09:41
input	[SimpleEntity:29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:217006] STT3 [nucleoplasm] [Gallus gallus]
literatureReference	[LiteratureReference:217161] Critical role for chicken Rad17 and Rad9 in the cellular response to DNA damage and stalled DNA replication
modified	[InstanceEdit:351413] Saxena, A, 2008-05-22 20:44:09 [InstanceEdit:374078] Saxena, A, 2008-07-25 17:02:19 [InstanceEdit:418476] D'Eustachio, P, 2009-04-22 20:40:00 [InstanceEdit:418618] D'Eustachio, P, 2009-04-24 15:53:07 [InstanceEdit:418966] D'Eustachio, P, 2009-04-27 17:13:45 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of Chk1 by ATR
output	[SimpleEntity:113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:217062] phospho-STT3 [nucleoplasm] [Gallus gallus]
precedingEvent	[Reaction:351412] Association of MRE11 and NBS1 leads to nuclear localization of MRN complex [Gallus gallus] [Reaction:351407] Association of MRE11 with RAD50 [Gallus gallus] [Reaction:217209] Generation of a DNA double strand break [Gallus gallus] [Reaction:265858] Activation of ATR by interaction with RAD9-TopBP1 complex [Gallus gallus] [Reaction:265823] Association between RAD9 and TopBP1 [Gallus gallus]
regulatedBy	[Requirement:217069] Requirement by 'Rad9-Hus1-Rad1(9-1-1) clamp [nucleoplasm]' [Requirement:217206] Requirement by 'Rad17-replication factor C (RFC), the clamp loader [nucleoplasm]'
releaseDate	2009-06-01
reviewed	[InstanceEdit:418616] Borowiec, JA, 2009-04-23 20:19:22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016553] R-GGA-216941.3
summation	[Summation:217193] Chk1 phosphorylation on Ser-345 is mediated by ATR kinase up...
(hasEvent)	[Pathway:217106] Chk1-controlled and DNA-damage induced centrosome duplication [Gallus gallus] [Pathway:351451] Homologous recombination repair of replication-dependent double-strand breaks [Gallus gallus]
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No pathways have been reviewed or authored by Phosphorylation of Chk1 by ATR (216941)