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Details on Person c-Abl is a ubiquitously-expressed non-receptor tyrosine kina...

Class:Id	Summation:216932
_displayName	c-Abl is a ubiquitously-expressed non-receptor tyrosine kina...
_timestamp	2009-02-23 15:56:33
created	[InstanceEdit:217050] Saxena, A, 2008-03-25 20:36:09
literatureReference	[LiteratureReference:216999] Arg encodes a widely expressed 145 kDa protein-tyrosine kinase [LiteratureReference:217096] Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation [LiteratureReference:217104] The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases [LiteratureReference:216973] Regulation of Rad51 function by c-Abl in response to DNA damage [LiteratureReference:217133] Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl
modified	[InstanceEdit:391641] Saxena, A, 2009-02-23 15:55:32
text	c-Abl is a ubiquitously-expressed non-receptor tyrosine kinase, which is activated in an ATM-dependent manner upon DNA damage. c-Abl plays a role in growth arrest and apoptosis as well as in DNA repair; the latter mediated by c-Abl phosphorylating Tyr46 on Rad51 (This residue corresponds to tyrosine 54 of human Rad51). Arg (Abl related gene) is another member of the Ableson cytoplasmic tyrosine kinase family. Its known functions are redundant with c-Abl.
(summation)	[Reaction:217013] Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members [Gallus gallus]
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