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Details on Person NOTCH3 binds DLL4

Class:IdReaction:2168136
_displayNameNOTCH3 binds DLL4
_doReleaseTRUE
_timestamp2017-11-02 15:24:28
authored[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
compartment[Compartment:876] plasma membrane
created[InstanceEdit:2168142] Orlic-Milacic, M, 2012-03-23
edited[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
entityOnOtherCell[EntityWithAccessionedSequence:158437] DLL4 [plasma membrane] [Homo sapiens]
goBiologicalProcess[GO_BiologicalProcess:20089] Notch signaling pathway
input[EntityWithAccessionedSequence:158437] DLL4 [plasma membrane] [Homo sapiens]
[Complex:157048] NOTCH3 [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2168139] Periodic Delta-like 4 expression in developing retinal arteries
[LiteratureReference:2168130] Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy
modified[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9012884] Orlic-Milacic, Marija, 2017-07-20
[InstanceEdit:9013068] Orlic-Milacic, Marija, 2017-07-21
[InstanceEdit:9013074] Orlic-Milacic, Marija, 2017-07-21
[InstanceEdit:9024182] Orlic-Milacic, Marija, 2017-10-02
[InstanceEdit:9027523] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9027526] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9027528] Orlic-Milacic, Marija, 2017-11-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNOTCH3 binds DLL4
output[Complex:2168132] DLL4:NOTCH3 [plasma membrane] [Homo sapiens]
releaseDate2017-12-13
reviewed[InstanceEdit:9027525] Haw, Robin, 2017-10-30
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8922714] R-HSA-2168136.2
summation[Summation:9013066] Binding of NOTCH3 receptor to DLL4 ligand has not been direc...
(hasEvent)[Pathway:9013507] NOTCH3 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(precedingEvent)[Reaction:9013069] Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 [Homo sapiens]
(replacementInstances)[_Deleted:9027574] Deletion of instance: 157644
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No pathways have been reviewed or authored by NOTCH3 binds DLL4 (2168136)