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Details on Person Processing of Proinsulin to Insulin

Class:IdBlackBoxEvent:216806
_displayNameProcessing of Proinsulin to Insulin
_doReleaseTRUE
_timestamp2017-02-27 02:47:40
authored[InstanceEdit:216805] May, B, 2008-03-22 08:26:49
catalystActivity[CatalystActivity:216665] zinc ion transmembrane transporter activity of Zinc Transporter8 (ZnT8) [Golgi membrane]
[CatalystActivity:216803] serine-type endopeptidase activity of Pcsk1 [secretory granule lumen]
[CatalystActivity:216789] serine-type endopeptidase activity of Convertase PC2 (in immature granule) [secretory granule lumen]
[CatalystActivity:216802] peptidase activity of Carboxypeptidase E (in immature granule) [secretory granule membrane]
compartment[Compartment:1462052] secretory granule lumen
[Compartment:216813] secretory granule membrane
[Compartment:20699] Golgi membrane
created[InstanceEdit:216805] May, B, 2008-03-22 08:26:49
edited[InstanceEdit:216805] May, B, 2008-03-22 08:26:49
input[Complex:216793] Proinsulin-Zinc-Calcium complex [secretory granule lumen] [Mus musculus]
literatureReference[LiteratureReference:264278] Zinc-ligand interactions modulate assembly and stability of the insulin hexamer -- a review
[LiteratureReference:264281] The role of assembly in insulin's biosynthesis
[LiteratureReference:264356] In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion
[LiteratureReference:264343] Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3
[LiteratureReference:264347] The proprotein convertases
[LiteratureReference:2684519] Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice
[LiteratureReference:8931827] SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells
modified[InstanceEdit:216815] May, B, 2008-03-22 08:36:08
[InstanceEdit:216816] May, B, 2008-03-23 13:47:11
[InstanceEdit:264227] May, B, 2008-03-29 11:00:57
[InstanceEdit:264341] May, B, 2008-03-30 13:31:59
[InstanceEdit:349831] May, B, 2008-05-13 12:50:17
[InstanceEdit:2684523] D'Eustachio, P, 2012-11-30
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8931835] May, Bruce, 2016-07-19
[InstanceEdit:8949118] May, Bruce, 2016-11-19
[InstanceEdit:8979396] May, Bruce, 2017-02-27
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameProcessing of Proinsulin to Insulin
output[Complex:216790] Insulin:Zinc:Calcium [secretory granule lumen] [Mus musculus]
[DefinedSet:216653] C peptide [secretory granule lumen] [Mus musculus]
precedingEvent
regulatedBy[Requirement:8949114] Requirement by 'Sorcs1 [Golgi membrane]'
regulationReference[RegulationReference:9641766] Requirement by 'Sorcs1 [Golgi membrane]' SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells
releaseDate2017-03-27
reviewed[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:8913834] R-MMU-216806.4
summation[Summation:264212] Proinsulin in proinsulin-zinc-calcium complexes is cleaved b...
(hasEvent)[Pathway:216455] Insulin Synthesis and Secretion [Mus musculus]
(inferredFrom)[Reaction:9023163] Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) [Homo sapiens]
[Reaction:9023178] PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) [Homo sapiens]
[Reaction:9023196] PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) [Homo sapiens]
(precedingEvent)[BlackBoxEvent:216852] Insulin secretory granule translocates to cell cortex [Mus musculus]
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No pathways have been reviewed or authored by Processing of Proinsulin to Insulin (216806)
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