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Details on Person SMAD7 binds to SMURF1 in the nucleus (Ebisawa et al. 2001, T...

Class:IdSummation:2167915
_displayNameSMAD7 binds to SMURF1 in the nucleus (Ebisawa et al. 2001, T...
_timestamp2012-04-16 19:51:46
created[InstanceEdit:2167914] Orlic-Milacic, M, 2012-03-23
literatureReference[LiteratureReference:178198] Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7
[LiteratureReference:2168995] Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity
[LiteratureReference:178173] Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
modified[InstanceEdit:2169000] Orlic-Milacic, M, 2012-03-26
[InstanceEdit:2197664] Orlic-Milacic, M, 2012-04-13
[InstanceEdit:2197821] Orlic-Milacic, M, 2012-04-16
[InstanceEdit:2199156] Orlic-Milacic, M, 2012-04-16
textSMAD7 binds to SMURF1 in the nucleus (Ebisawa et al. 2001, Tajima et al. 2003). SMURF1 domains WW1 and WW2, highly similar to WW2 and WW3 domains of SMURF2, are involved in SMAD7 binding. SMURF1 has two splicing isoforms. The shorter splicing isoform of SMURF1 has an inter-WW domain linker of the same length as the WW2-WW3 domain linker of SMURF2. The longer isoform of SMURF1 has a longer WW1-WW2 domain linker, resulting in decreased affinity of the longer SMURF1 isoform for SMAD7 (Chong et al. 2010). This is based on experiments with recombinant mouse Smad7 and recombinant human SMURF1.
(summation)[Reaction:2167917] SMAD7 binds to SMURF1 [Homo sapiens]
[Reaction:9846252] GOCAM SMAD7 binds to SMURF1 [Homo sapiens]
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