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Details on Person Formation of Proinsulin-Zinc-Calcium Complex

Class:Id	BlackBoxEvent:216660
_displayName	Formation of Proinsulin-Zinc-Calcium Complex
_timestamp	2016-07-15 23:50:20
catalystActivity	[CatalystActivity:216777] zinc ion transmembrane transporter activity of Zinc Transporter 6 (ZnT6) [Golgi membrane] [CatalystActivity:216664] zinc ion transmembrane transporter activity of Zinc Transporter5 (ZnT5) [secretory granule membrane] [CatalystActivity:216781] zinc ion transmembrane transporter activity of Zinc Transporter 7 (ZnT7) [Golgi membrane] [CatalystActivity:216782] zinc ion transmembrane transporter activity of Zinc Transporter 1 (ZnT1) [plasma membrane]
compartment	[Compartment:17963] Golgi lumen
created	[InstanceEdit:216668] May, B, 2008-03-19 13:25:42
input	[DefinedSet:216661] Proinsulin [Golgi lumen] [Mus musculus] [SimpleEntity:167012] Ca2+ [Golgi lumen] [SimpleEntity:216667] Zn2+ [Golgi lumen]
literatureReference	[LiteratureReference:264278] Zinc-ligand interactions modulate assembly and stability of the insulin hexamer -- a review [LiteratureReference:264281] The role of assembly in insulin's biosynthesis [LiteratureReference:264279] Overview of mammalian zinc transporters
modified	[InstanceEdit:216779] May, B, 2008-03-22 08:23:27 [InstanceEdit:264220] May, B, 2008-03-29 10:51:54 [InstanceEdit:264282] May, B, 2008-03-30 13:18:44 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	Formation of Proinsulin-Zinc-Calcium Complex
output	[Complex:216670] Proinsulin-Zinc-Calcium complex [Golgi lumen] [Mus musculus]
precedingEvent	[BlackBoxEvent:216673] Transport of Proinsulin from the Endoplasmic Reticulum to the Golgi [Mus musculus] [Reaction:216687] Oxidation of Cysteine to Cystine Bonds in Proinsulin [Mus musculus]
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:8917687] R-MMU-216660.1
summation	[Summation:216774] Zinc Transporters ZnT5, ZnT6, and ZnT7 are found in the memb...
(hasEvent)	[Pathway:216455] Insulin Synthesis and Secretion [Mus musculus]
(precedingEvent)	[BlackBoxEvent:216810] Proinsulin translocates to immature secretory granule [Mus musculus]
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No pathways have been reviewed or authored by Formation of Proinsulin-Zinc-Calcium Complex (216660)