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Details on Person UniProt:P21661 Pcsk2
Class:Id
ReferenceGeneProduct:216448
_chainChangeLog
signal peptide:1-24 added on Fri February 6 2015;propeptide:25-108 added on Fri February 6 2015;chain:109-637 added on Fri February 6 2015
_displayName
UniProt:P21661 Pcsk2
_timestamp
2023-11-03 15:38:08
chain
signal peptide:1-24 propeptide:25-108 chain:109-637
checksum
B69F2DCCD00FB0E6
comment
FUNCTION Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity).CATALYTIC ACTIVITY Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.SUBCELLULAR LOCATION Localized in the secretion granules.SIMILARITY Belongs to the peptidase S8 family. Furin subfamily.
Cleavage on pair of basic residues Cytoplasmic vesicle Disulfide bond Glycoprotein Hydrolase Protease Reference proteome Secreted Serine protease Signal Zymogen
