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Details on Person UniProt:P97760 Polr2c
| Class:Id | ReferenceGeneProduct:216424 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-275 added on Fri February 6 2015 |
| _displayName | UniProt:P97760 Polr2c |
| _timestamp | 2024-11-03 19:38:37 |
| chain | chain:1-275 |
| checksum | 64C3E2F61B91B352 |
| comment | FUNCTION Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates.SUBUNIT Component of the RNA polymerase II (Pol II) core complex consisting of 12 subunits: a ten-subunit catalytic core composed of POLR2A/RPB1, POLR2B/RPB2, POLR2C/RPB3, POLR2I/RPB9, POLR2J/RPB11, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5 and a mobile stalk composed of two subunits POLR2D/RPB4 and POLR2G/RPB7, protruding from the core and functioning primarily in transcription initiation. Part of Pol II(G) complex, in which Pol II core associates with an additional subunit POLR2M; unlike conventional Pol II, Pol II(G) functions as a transcriptional repressor. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms. Interacts with PTPN6; this interaction promotes the recruitment of RNA pol II to the PCK1 promoter.SUBCELLULAR LOCATION Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. |
| created | [InstanceEdit:216466] May, B, 2008-03-16 08:26:23 |
| description | recommendedName: fullName evidence="4"DNA-directed RNA polymerase II subunit RPB3 shortName: RNA polymerase II subunit 3 shortName: RNA polymerase II subunit B3 alternativeName: DNA-directed RNA polymerase II 33 kDa polypeptide shortName: RPB33 alternativeName: DNA-directed RNA polymerase II subunit C alternativeName: fullName evidence="3"RPB31 |
| geneName | Polr2c Rpo2-3 |
| identifier | P97760 |
| isSequenceChanged | FALSE |
| keyword | DNA-directed RNA polymerase Nucleus Phosphoprotein Reference proteome Transcription |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | Polr2c |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RPB3_MOUSE Q99M46 |
| sequenceLength | 275 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:216461] RNA polymerase II subunit RPB3 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9967344] Polr2c [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P97760 Polr2c (216424)
