Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Recruitment of RNA polymerase II to Insulin Gene promoter

Class:Id	Reaction:216419
_displayName	Recruitment of RNA polymerase II to Insulin Gene promoter
_timestamp	2018-01-14 06:50:29
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:216466] May, B, 2008-03-16 08:26:23
input	[Complex:216465] Pre-transcriptional complex (insulin gene) [nucleoplasm] [Mus musculus] [Complex:216411] RNA polymerase II holoenzyme (generic) [nucleoplasm] [Mus musculus]
literatureReference	[LiteratureReference:264233] Regulation of the insulin gene by glucose and fatty acids [LiteratureReference:264371] Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters [LiteratureReference:264366] Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression [LiteratureReference:264360] Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1 [LiteratureReference:264364] Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes [LiteratureReference:264369] The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter [LiteratureReference:187371] Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA [LiteratureReference:264361] Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression [LiteratureReference:264363] The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription
modified	[InstanceEdit:264228] May, B, 2008-03-29 11:01:49 [InstanceEdit:264368] May, B, 2008-03-30 13:35:18 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9034898] May, Bruce, 2018-01-14
name	Recruitment of RNA polymerase II to Insulin Gene promoter
output	[Complex:216422] Transcriptional complex (Insulin gene) [nucleoplasm] [Mus musculus]
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:8885657] R-MMU-216419.1
summation	[Summation:264213] The transcription factors Pdx-1, MafA, E47, and Beta2/Neuro-...
(hasEvent)	[Pathway:216455] Insulin Synthesis and Secretion [Mus musculus]
(precedingEvent)	[BlackBoxEvent:216409] Transcription of Insulin Genes [Mus musculus]
[Change default viewing format]

No pathways have been reviewed or authored by Recruitment of RNA polymerase II to Insulin Gene promoter (216419)