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Details on Person UniProt:P63239 Pcsk1
| Class:Id | ReferenceGeneProduct:216397 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Sat February 7 2015;propeptide:28-110 added on Sat February 7 2015;chain:111-753 added on Sat February 7 2015 |
| _displayName | UniProt:P63239 Pcsk1 |
| _timestamp | 2023-11-03 15:50:13 |
| chain | signal peptide:1-27 propeptide:28-110 chain:111-753 |
| checksum | 04239C7B6385382E |
| comment | FUNCTION Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.CATALYTIC ACTIVITY Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.COFACTOR Optimum pH is 5.5-6.5.INTERACTION Localized in the secretion granules.DISRUPTION PHENOTYPE Increase in unprocessed AGRP.SIMILARITY Belongs to the peptidase S8 family. Furin subfamily. |
| created | [InstanceEdit:216466] May, B, 2008-03-16 08:26:23 |
| description | recommendedName: Neuroendocrine convertase 1 shortName: NEC 1 ecNumber: 3.4.21.93 alternativeName: Furin homolog alternativeName: PC3 alternativeName: Prohormone convertase 1 alternativeName: Propeptide-processing protease alternativeName: Proprotein convertase 1 shortName: PC1 |
| geneName | Pcsk1 Att-1 Nec-1 Nec1 |
| identifier | P63239 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calcium Cleavage on pair of basic residues Cytoplasmic vesicle Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Protease Reference proteome Serine protease Signal Zymogen |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Pcsk1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NEC1_MOUSE P21662 P22546 |
| sequenceLength | 753 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:181794] Proprotein convertase 1 [endoplasmic reticulum lumen] [Mus musculus] [EntityWithAccessionedSequence:216794] Pcsk1 [secretory granule lumen] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P63239 Pcsk1 (216397)
