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Details on Person Hedgehog regulates smoothened activity by inducing a conformational switch

Class:Id	LiteratureReference:216257
_displayName	Hedgehog regulates smoothened activity by inducing a conformational switch
_timestamp	2008-03-11 15:50:40
author	[Person:182321] Zhao, Y [Person:207980] Tong, C [Person:207095] Jiang, J
created	[InstanceEdit:216199] Williams, MG, 2008-03-11 15:41:17
journal	Nature
pages	252-8
pubMedIdentifier	17960137
title	Hedgehog regulates smoothened activity by inducing a conformational switch
volume	450
year	2007
(literatureReference)	[Reaction:209253] Autophosphorylated FU phosphorylates COS [Drosophila melanogaster] [Reaction:216202] Phosphorylated SMO changes conformation and is activated [Drosophila melanogaster] [BlackBoxEvent:5610763] PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal [Homo sapiens] [Reaction:5632661] Csnk1a1 phosphorylates Smo dimer [Mus musculus] [Reaction:5632663] Adrbk1 binds pS592, S594, T597, S599 Smo dimer:Csnk1a1 [Mus musculus] [BlackBoxEvent:5632668] SMO translocates to the cilium [Homo sapiens] [Reaction:5632670] CSNK1A1 phosphorylates SMO dimer [Homo sapiens] [Reaction:5632671] CSNK1A1 binds SMO dimer [Homo sapiens] [Reaction:5632672] ADRBK1 phosphorylates SMO dimer [Homo sapiens] [Reaction:5632674] ADRBK1 binds phosphorylated SMO dimer [Homo sapiens] List all 12 refering instances
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