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Details on Person HHB is hydroxylated to DHHB by Coq6

Class:Id	Reaction:2162292
_displayName	HHB is hydroxylated to DHHB by Coq6
_doRelease	TRUE
_timestamp	2024-05-02 09:03:55
authored	[InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity	[CatalystActivity:2162279] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of Coq6:FAD [mitochondrial inner membrane]
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:2162311] Williams, MG, 2012-03-19
crossReference	[DatabaseIdentifier:9856084] RHEA:20362
edited	[InstanceEdit:2167908] Williams, MG, 2012-03-23
input	[SimpleEntity:2162330] HHB [mitochondrial matrix] [SimpleEntity:113533] O2 [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:2395504] (2Fe-2S)(1+) [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:2162288] Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency [LiteratureReference:2162300] The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis [LiteratureReference:9909196] Activation of Coq6p, a FAD Monooxygenase Involved in Coenzyme Q Biosynthesis, by Adrenodoxin Reductase/Ferredoxin [LiteratureReference:9909211] In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis
modified	[InstanceEdit:2162344] Williams, MG, 2012-03-19 [InstanceEdit:2167896] Williams, MG, 2012-03-23 [InstanceEdit:2167937] Williams, MG, 2012-03-23 [InstanceEdit:2201174] Williams, MG, 2012-04-17 [InstanceEdit:2237879] D'Eustachio, P, 2012-05-07 [InstanceEdit:3009434] D'Eustachio, P, 2013-02-05 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856086] Stephan, Ralf, 2023-12-10 [InstanceEdit:9863301] Matthews, Lisa, 2024-02-28 [InstanceEdit:9909195] Stephan, Ralf, 2024-04-30 [InstanceEdit:9909266] Stephan, Ralf, 2024-05-02
name	HHB is hydroxylated to DHHB by Coq6
output	[SimpleEntity:2162278] DHHB [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:2395501] (2Fe-2S)2+ [mitochondrial matrix]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-03-12
reviewed	[InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05 [InstanceEdit:9863300] Matthews, Lisa, 2024-02-28 [InstanceEdit:9909268] Pierrel, Fabien, 2024-05-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:68322] Saccharomyces cerevisiae
stableIdentifier	[StableIdentifier:3200320] R-SCE-2162292.4
structureModified	[InstanceEdit:9856086] Stephan, Ralf, 2023-12-10
summation	[Summation:2167898] A flavin-dependent monooxygenase involved in ubiquinone/ubiq...
(hasEvent)	[Pathway:2142675] Ubiquinol Biosynthesis pathway - Inferred Events
(updatedInstance)	[_UpdateTracker:9864108] Update Tracker - [Reaction:2162292] HHB is hydroxylated to DHHB by Coq6 - v88:[add_removeInput, add_removeOutput, modifyText]
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