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Details on Person COQ2 ligates all-E-10PrP2 to PHB
Class:Id Reaction:2162192
_displayName COQ2 ligates all-E-10PrP2 to PHB
_doRelease TRUE
_timestamp 2024-05-15 08:07:51
authored [InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity [CatalystActivity:2162263] 4-hydroxybenzoate polyprenyltransferase activity of COQ2 [mitochondrial inner membrane]
compartment [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created [InstanceEdit:2162189] Williams, MG, 2012-03-15
crossReference [DatabaseIdentifier:9855953] RHEA:44565
edited [InstanceEdit:2167908] Williams, MG, 2012-03-23
input [SimpleEntity:2162213] PHB [mitochondrial matrix] [SimpleEntity:2162214] all-E-10PrP2 [mitochondrial inner membrane]
internalReviewed [InstanceEdit:9857489] D'Eustachio, Peter, 2024-01-07
isChimeric FALSE
literatureReference [LiteratureReference:2162258] Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ [LiteratureReference:2162268] Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells [LiteratureReference:9856238] Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis
modified [InstanceEdit:2162203] Williams, MG, 2012-03-15 [InstanceEdit:2162270] Williams, MG, 2012-03-19 [InstanceEdit:2167896] Williams, MG, 2012-03-23 [InstanceEdit:2167937] Williams, MG, 2012-03-23 [InstanceEdit:2201174] Williams, MG, 2012-04-17 [InstanceEdit:2237879] D'Eustachio, P, 2012-05-07 [InstanceEdit:3009434] D'Eustachio, P, 2013-02-05 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9855952] Stephan, Ralf, 2023-12-09 [InstanceEdit:9856086] Stephan, Ralf, 2023-12-10 [InstanceEdit:9856244] Stephan, Ralf, 2023-12-14 [InstanceEdit:9857488] Stephan, Ralf, 2024-01-07 [InstanceEdit:9864526] Stephan, Ralf, 2024-03-07 [InstanceEdit:9909266] Stephan, Ralf, 2024-05-02 [InstanceEdit:9909592] Stephan, Ralf, 2024-05-14 [InstanceEdit:9910562] Stephan, Ralf, 2024-05-15
name COQ2 ligates all-E-10PrP2 to PHB PHB and all-E-10PrP2 are combined into DHB by COQ2
output [SimpleEntity:2162207] DHB [mitochondrial inner membrane] [SimpleEntity:159450] PPi [mitochondrial matrix]
precedingEvent
releaseDate 2013-03-12
reviewed [InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05 [InstanceEdit:9909268] Pierrel, Fabien, 2024-05-02 [InstanceEdit:9909593] Marchi, Marco, 2024-05-14 [InstanceEdit:9910563] Tonello, Fiorella, 2024-05-15
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:3200342] R-HSA-2162192.5
summation [Summation:2167900] 4-Hydroxybenzoate polyprenyltransferase (COQ2) catalyses the...
(hasEvent) [Pathway:2142789] Ubiquinol biosynthesis [Homo sapiens]
(precedingEvent) [Reaction:2162187] COQ6 hydroxylates DHB [Homo sapiens]
(updatedInstance) [_UpdateTracker:9864330] Update Tracker - [Reaction:2162192] COQ2 ligates all-E-10PrP2 to PHB - v88:[addLiteratureReference, modifyText]
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