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Details on Person COQ2 ligates all-E-10PrP2 to PHB

Class:IdReaction:2162192
_displayNameCOQ2 ligates all-E-10PrP2 to PHB
_doReleaseTRUE
_timestamp2024-05-15 08:07:51
authored[InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity[CatalystActivity:2162263] 4-hydroxybenzoate polyprenyltransferase activity of COQ2 [mitochondrial inner membrane]
compartment[Compartment:70616] mitochondrial inner membrane
[Compartment:5460] mitochondrial matrix
created[InstanceEdit:2162189] Williams, MG, 2012-03-15
crossReference[DatabaseIdentifier:9855953] RHEA:44565
edited[InstanceEdit:2167908] Williams, MG, 2012-03-23
input[SimpleEntity:2162213] PHB [mitochondrial matrix]
[SimpleEntity:2162214] all-E-10PrP2 [mitochondrial inner membrane]
internalReviewed[InstanceEdit:9857489] D'Eustachio, Peter, 2024-01-07
isChimericFALSE
literatureReference[LiteratureReference:2162258] Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ
[LiteratureReference:2162268] Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells
[LiteratureReference:9856238] Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis
modified[InstanceEdit:2162203] Williams, MG, 2012-03-15
[InstanceEdit:2162270] Williams, MG, 2012-03-19
[InstanceEdit:2167896] Williams, MG, 2012-03-23
[InstanceEdit:2167937] Williams, MG, 2012-03-23
[InstanceEdit:2201174] Williams, MG, 2012-04-17
[InstanceEdit:2237879] D'Eustachio, P, 2012-05-07
[InstanceEdit:3009434] D'Eustachio, P, 2013-02-05
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9855952] Stephan, Ralf, 2023-12-09
[InstanceEdit:9856086] Stephan, Ralf, 2023-12-10
[InstanceEdit:9856244] Stephan, Ralf, 2023-12-14
[InstanceEdit:9857488] Stephan, Ralf, 2024-01-07
[InstanceEdit:9864526] Stephan, Ralf, 2024-03-07
[InstanceEdit:9909266] Stephan, Ralf, 2024-05-02
[InstanceEdit:9909592] Stephan, Ralf, 2024-05-14
[InstanceEdit:9910562] Stephan, Ralf, 2024-05-15
nameCOQ2 ligates all-E-10PrP2 to PHB
PHB and all-E-10PrP2 are combined into DHB by COQ2
output[SimpleEntity:2162207] DHB [mitochondrial inner membrane]
[SimpleEntity:159450] PPi [mitochondrial matrix]
precedingEvent
releaseDate2013-03-12
reviewed[InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05
[InstanceEdit:9909268] Pierrel, Fabien, 2024-05-02
[InstanceEdit:9909593] Marchi, Marco, 2024-05-14
[InstanceEdit:9910563] Tonello, Fiorella, 2024-05-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200342] R-HSA-2162192.5
summation[Summation:2167900] 4-Hydroxybenzoate polyprenyltransferase (COQ2) catalyses the...
(hasEvent)[Pathway:2142789] Ubiquinol biosynthesis [Homo sapiens]
(precedingEvent)[Reaction:2162187] COQ6 hydroxylates DHB [Homo sapiens]
(updatedInstance)[_UpdateTracker:9864330] Update Tracker - [Reaction:2162192] COQ2 ligates all-E-10PrP2 to PHB - v88:[addLiteratureReference, modifyText]
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