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Details on Person Unknown enzyme hydroxylates DMPhOH

Class:Id	BlackBoxEvent:2162191
_displayName	Unknown enzyme hydroxylates DMPhOH
_doRelease	TRUE
_timestamp	2024-05-15 08:10:01
authored	[InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity	[CatalystActivity:2167847] monooxygenase activity of DMPhOH monooxygenase [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:2162189] Williams, MG, 2012-03-15
edited	[InstanceEdit:2167908] Williams, MG, 2012-03-23
inferredFrom	[BlackBoxEvent:2164813] HMPhOH is hydroxylated to MDMQ6H2 by HMPhOH monooxygenase [Saccharomyces cerevisiae]
input	[SimpleEntity:2162208] DMPhOH [mitochondrial inner membrane] [SimpleEntity:113533] O2 [mitochondrial matrix] [SimpleEntity:113600] NADPH [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
internalReviewed	[InstanceEdit:9857489] D'Eustachio, Peter, 2024-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:2162288] Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency [LiteratureReference:2162300] The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis [LiteratureReference:9909191] COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells [LiteratureReference:9909211] In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis
modified	[InstanceEdit:2162203] Williams, MG, 2012-03-15 [InstanceEdit:2162270] Williams, MG, 2012-03-19 [InstanceEdit:2164806] Williams, MG, 2012-03-20 [InstanceEdit:2167849] Williams, MG, 2012-03-22 [InstanceEdit:2167896] Williams, MG, 2012-03-23 [InstanceEdit:2167937] Williams, MG, 2012-03-23 [InstanceEdit:2201174] Williams, MG, 2012-04-17 [InstanceEdit:2237879] D'Eustachio, P, 2012-05-07 [InstanceEdit:3009434] D'Eustachio, P, 2013-02-05 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856090] Stephan, Ralf, 2023-12-10 [InstanceEdit:9857488] Stephan, Ralf, 2024-01-07 [InstanceEdit:9909243] Stephan, Ralf, 2024-05-01 [InstanceEdit:9909266] Stephan, Ralf, 2024-05-02 [InstanceEdit:9909592] Stephan, Ralf, 2024-05-14 [InstanceEdit:9910562] Stephan, Ralf, 2024-05-15
name	Unknown enzyme hydroxylates DMPhOH DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase
output	[SimpleEntity:2162205] MDMQ10H2 [mitochondrial inner membrane] [SimpleEntity:113563] NADP+ [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix]
precedingEvent	[Reaction:2162195] COQ4 decarboxylates MHDB [Homo sapiens] [Reaction:2162193] COQ3 methylates DHDB [Homo sapiens]
releaseDate	2013-03-12
reviewed	[InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05 [InstanceEdit:9909268] Pierrel, Fabien, 2024-05-02 [InstanceEdit:9909593] Marchi, Marco, 2024-05-14 [InstanceEdit:9910563] Tonello, Fiorella, 2024-05-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200555] R-HSA-2162191.5
summation	[Summation:2167905] The enzymatic conversion of 2-methoxy-6-decaprenylphenol (DM...
(hasEvent)	[Pathway:2142789] Ubiquinol biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:2162188] COQ5 methylates MDMQ10H2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9910941] Update Tracker - [BlackBoxEvent:2162191] Unknown enzyme hydroxylates DMPhOH - v89:[addLiteratureReference, modifyText]
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