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Details on Person COQ5 methylates MDMQ10H2

Class:Id	Reaction:2162188
_displayName	COQ5 methylates MDMQ10H2
_doRelease	TRUE
_timestamp	2024-05-15 08:08:35
authored	[InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity	[CatalystActivity:2167835] 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity of COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:2162189] Williams, MG, 2012-03-15
crossReference	[DatabaseIdentifier:9856131] RHEA:44765
edited	[InstanceEdit:2167908] Williams, MG, 2012-03-23
input	[SimpleEntity:2162205] MDMQ10H2 [mitochondrial inner membrane] [SimpleEntity:2162265] AdoMet [mitochondrial matrix]
internalReviewed	[InstanceEdit:9857489] D'Eustachio, Peter, 2024-01-07
isChimeric	FALSE
literatureReference	[LiteratureReference:2167837] Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis [LiteratureReference:9856267] Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis [LiteratureReference:9856264] Disruption of the human COQ5-containing protein complex is associated with diminished coenzyme Q10 levels under two different conditions of mitochondrial energy deficiency [LiteratureReference:9856262] Detection of suppressed maturation of the human COQ5 protein in the mitochondria following mitochondrial uncoupling by an antibody recognizing both precursor and mature forms of COQ5 [LiteratureReference:9909211] In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis
modified	[InstanceEdit:2162203] Williams, MG, 2012-03-15 [InstanceEdit:2162270] Williams, MG, 2012-03-19 [InstanceEdit:2167849] Williams, MG, 2012-03-22 [InstanceEdit:2167896] Williams, MG, 2012-03-23 [InstanceEdit:2167937] Williams, MG, 2012-03-23 [InstanceEdit:2201174] Williams, MG, 2012-04-17 [InstanceEdit:2237879] D'Eustachio, P, 2012-05-07 [InstanceEdit:3009434] D'Eustachio, P, 2013-02-05 [InstanceEdit:8855124] D'Eustachio, Peter, 2016-02-01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856130] Stephan, Ralf, 2023-12-11 [InstanceEdit:9856258] Stephan, Ralf, 2023-12-15 [InstanceEdit:9857488] Stephan, Ralf, 2024-01-07 [InstanceEdit:9909265] Stephan, Ralf, 2024-05-02 [InstanceEdit:9909266] Stephan, Ralf, 2024-05-02 [InstanceEdit:9909592] Stephan, Ralf, 2024-05-14 [InstanceEdit:9910562] Stephan, Ralf, 2024-05-15
name	COQ5 methylates MDMQ10H2 MDMQ10H2 is methylated to DMQ10H2 by COQ5
output	[SimpleEntity:2162204] DMQ10H2 [mitochondrial inner membrane] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:2162191] Unknown enzyme hydroxylates DMPhOH [Homo sapiens] [Reaction:2162195] COQ4 decarboxylates MHDB [Homo sapiens] [Reaction:8855062] SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy [Homo sapiens] [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens]
releaseDate	2013-03-12
reviewed	[InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05 [InstanceEdit:9909268] Pierrel, Fabien, 2024-05-02 [InstanceEdit:9909593] Marchi, Marco, 2024-05-14 [InstanceEdit:9910563] Tonello, Fiorella, 2024-05-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200220] R-HSA-2162188.6
summation	[Summation:2167902] 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase (COQ5) cata...
(hasEvent)	[Pathway:2142789] Ubiquinol biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:2162194] COQ7:COQ9 octamer hydroxylates DMQ10H2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9864232] Update Tracker - [Reaction:2162188] COQ5 methylates MDMQ10H2 - v88:[addLiteratureReference, modifyText] [_UpdateTracker:9911113] Update Tracker - [Reaction:2162188] COQ5 methylates MDMQ10H2 - v89:[addLiteratureReference, modifyText]
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