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Details on Person COQ3 methylates DeMQ10H2
Class:Id Reaction:2162186
_displayName COQ3 methylates DeMQ10H2
_doRelease TRUE
_timestamp 2024-05-15 08:08:14
authored [InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity [CatalystActivity:2162293] 3-demethylubiquinol 3-O-methyltransferase activity of COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane]
compartment [Compartment:5460] mitochondrial matrix
created [InstanceEdit:2162189] Williams, MG, 2012-03-15
crossReference [DatabaseIdentifier:9856132] RHEA:44413
edited [InstanceEdit:2167908] Williams, MG, 2012-03-23
input [SimpleEntity:2162212] DeMQ10H2 [mitochondrial inner membrane] [SimpleEntity:2162265] AdoMet [mitochondrial matrix]
internalReviewed [InstanceEdit:9857489] D'Eustachio, Peter, 2024-01-07
isChimeric FALSE
literatureReference [LiteratureReference:2162320] Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis [LiteratureReference:9856230] Structural and biochemical studies reveal UbiG/Coq3 as a class of novel membrane-binding proteins [LiteratureReference:9909211] In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis
modified [InstanceEdit:2162203] Williams, MG, 2012-03-15 [InstanceEdit:2162270] Williams, MG, 2012-03-19 [InstanceEdit:2162311] Williams, MG, 2012-03-19 [InstanceEdit:2167896] Williams, MG, 2012-03-23 [InstanceEdit:2167937] Williams, MG, 2012-03-23 [InstanceEdit:2201174] Williams, MG, 2012-04-17 [InstanceEdit:2237879] D'Eustachio, P, 2012-05-07 [InstanceEdit:3009434] D'Eustachio, P, 2013-02-05 [InstanceEdit:8855124] D'Eustachio, Peter, 2016-02-01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9856130] Stephan, Ralf, 2023-12-11 [InstanceEdit:9856244] Stephan, Ralf, 2023-12-14 [InstanceEdit:9857488] Stephan, Ralf, 2024-01-07 [InstanceEdit:9909265] Stephan, Ralf, 2024-05-02 [InstanceEdit:9909266] Stephan, Ralf, 2024-05-02 [InstanceEdit:9909592] Stephan, Ralf, 2024-05-14 [InstanceEdit:9910562] Stephan, Ralf, 2024-05-15
name COQ3 methylates DeMQ10H2 DeMQ10H2 is methylated to Q10H2 by COQ3
output [SimpleEntity:2162198] CoQH2 [mitochondrial inner membrane] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent
releaseDate 2012-03-13
reviewed [InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05 [InstanceEdit:9909268] Pierrel, Fabien, 2024-05-02 [InstanceEdit:9909593] Marchi, Marco, 2024-05-14 [InstanceEdit:9910563] Tonello, Fiorella, 2024-05-15
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:3200150] R-HSA-2162186.6
summation [Summation:2167903] Mitochondrial COQ3 is an O-methyltransferase required in the...
(hasEvent) [Pathway:2142789] Ubiquinol biosynthesis [Homo sapiens]
(precedingEvent) [Reaction:9856502] mito-STARD7 transports Q10 to outer mitochondrial membrane [Homo sapiens]
(updatedInstance) [_UpdateTracker:9864082] Update Tracker - [Reaction:2162186] COQ3 methylates DeMQ10H2 - v88:[addLiteratureReference] [_UpdateTracker:9910963] Update Tracker - [Reaction:2162186] COQ3 methylates DeMQ10H2 - v89:[addLiteratureReference, modifyText]
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