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Details on Person Hepoxilins are biologically relevant signalling molecules pr...
| Class:Id | Summation:2162107 |
|---|---|
| _displayName | Hepoxilins are biologically relevant signalling molecules pr... |
| _timestamp | 2012-03-14 15:34:01 |
| created | [InstanceEdit:2162144] Williams, MG, 2012-03-14 |
| text | Hepoxilins are biologically relevant signalling molecules produced by certain arachidonate 12-lipoxygenase (ALOX12s). Hepoxilin A3 (HXA3) and B3 (HXB3) have been identified, both of which incorporate an epoxide across the C-11 and C-12 double bond, as well as an additional hydroxyl moiety. HXA3 has a C-8 hydroxyl, whereas the HXB3 hydroxyl occurs at C-10. The epoxy moiety is labile and can be hydrolyzed either by a hepoxilin specific epoxide hydrolase (HXEH) or in acidic aqueous solution to form the corresponding diol metabolites trioxilin A3 (TrXA3) and B3 (TrXB3) (Buczynski et al. 2009, Vance & Vance 2008). |
| (summation) | [Pathway:2142696] Synthesis of Hepoxilins (HX) and Trioxilins (TrX) [Homo sapiens] |
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No pathways have been reviewed or authored by Hepoxilins are biologically relevant signalling molecules pr... (2162107)
