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Details on Person carbovir + IMP => carbovir monophosphate + inosine

Class:Id	Reaction:2162066
_displayName	carbovir + IMP => carbovir monophosphate + inosine
_doRelease	TRUE
_timestamp	2012-05-31 09:37:36
authored	[InstanceEdit:2162171] D'Eustachio, P, 2012-03-14
catalystActivity	[CatalystActivity:2161536] nucleoside phosphotransferase activity of NT5C2 tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2162100] D'Eustachio, P, 2012-03-14
edited	[InstanceEdit:2162250] D'Eustachio, P, 2012-03-16
input	[ChemicalDrug:2161514] carbovir [cytosol] [SimpleEntity:29602] IMP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:2161513] Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells [LiteratureReference:2161101] Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity [LiteratureReference:109314] High Km soluble 5'-nucleotidase from human placenta [LiteratureReference:500117] Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition
modified	[InstanceEdit:2162101] D'Eustachio, P, 2012-03-14 [InstanceEdit:2162170] D'Eustachio, P, 2012-03-14 [InstanceEdit:2162240] D'Eustachio, P, 2012-03-16 [InstanceEdit:2162249] D'Eustachio, P, 2012-03-16 [InstanceEdit:2247553] D'Eustachio, P, 2012-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	carbovir + IMP => carbovir monophosphate + inosine Conversion of carbovir to carbovir monophosphate
output	[ChemicalDrug:2161176] carbovir monophosphate [cytosol] [SimpleEntity:83927] Ino [cytosol]
releaseDate	2012-06-12
reviewed	[InstanceEdit:2162241] Jassal, B, 2012-03-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2294649] R-HSA-2162066.2
summation	[Summation:2162065] NT5C2 catalyzes the reaction of carbovir and IMP to form car...
(hasEvent)	[Pathway:2161541] Abacavir metabolism [Homo sapiens]
(precedingEvent)	[Reaction:2162092] carbovir monophosphate + ATP => carbovir diphosphate + ADP [Homo sapiens]
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No pathways have been reviewed or authored by carbovir + IMP => carbovir monophosphate + inosine (2162066)