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Details on Person Phosphorylated SMO changes conformation and is activated

Class:Id	Reaction:216202
_displayName	Phosphorylated SMO changes conformation and is activated
_doRelease	TRUE
_timestamp	2021-08-03 16:33:25
authored	[InstanceEdit:386946] Williams, MG, 2006-12-07 16:49:12
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:216199] Williams, MG, 2008-03-11 15:41:17
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
figure	[Figure:216256] /figures/DrosHHB19.jpg
input	[Complex:206727] Phospho (9 sites) SMO:COS:CI:FU [plasma membrane] [Drosophila melanogaster]
literatureReference	[LiteratureReference:216257] Hedgehog regulates smoothened activity by inducing a conformational switch [LiteratureReference:208065] Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I [LiteratureReference:216183] Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened [LiteratureReference:216277] Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation [LiteratureReference:208158] Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
modified	[InstanceEdit:350534] Williams, MG, 2008-05-19 14:35:41 [InstanceEdit:386962] Williams, MG, 2008-11-27 15:15:51 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9024541] Matthews, Lisa, 2017-10-05 [InstanceEdit:9038602] D'Eustachio, Peter, 2018-03-09 [InstanceEdit:9749431] Matthews, Lisa, 2021-08-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated SMO changes conformation and is activated
output	[Complex:216158] Phospho (9 sites) Act SMO:COS:CI:FU [plasma membrane] [Drosophila melanogaster]
precedingEvent	[Reaction:209168] Phosphorylation of SMO by CKIalpha [Drosophila melanogaster] [Reaction:209341] Phosphorylation of SMO by PKA-C1 [Drosophila melanogaster]
releaseDate	2017-09-12
reviewed	[InstanceEdit:386945] Kalderon, D, 2008-03-17 11:00:25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:56210] Drosophila melanogaster
stableIdentifier	[StableIdentifier:8905644] R-DME-216202.5
summation	[Summation:216198] The Smoothened (SMO) large terminal cytoplasmic domain chang...
(hasEvent)	[Pathway:216217] Activation of SMO [Drosophila melanogaster]
(precedingEvent)	[Reaction:209253] Autophosphorylated FU phosphorylates COS [Drosophila melanogaster]
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No pathways have been reviewed or authored by Phosphorylated SMO changes conformation and is activated (216202)